N-(5-allyl-2-(2,4-difluorophenyl)-7,7-difluoro-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-3-yl)-3-phenoxypropanamide

Base Information

Chemical Name:N-(5-allyl-2-(2,4-difluorophenyl)-7,7-difluoro-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-3-yl)-3-phenoxypropanamide
CAS No.:1451076-49-5
Molecular Formula:C₃₁H₂₈F₄N₄O₃
Molecular Weight:580.582
Hs Code.:

Synonyms:N-(5-allyl-2-(2,4-difluorophenyl)-7,7-difluoro-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-3-yl)-3-phenoxypropanamide

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Chemical Property of N-(5-allyl-2-(2,4-difluorophenyl)-7,7-difluoro-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-3-yl)-3-phenoxypropanamide

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Technology Process of N-(5-allyl-2-(2,4-difluorophenyl)-7,7-difluoro-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-3-yl)-3-phenoxypropanamide

There total 4 articles about N-(5-allyl-2-(2,4-difluorophenyl)-7,7-difluoro-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-3-yl)-3-phenoxypropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 28317-96-6
3-phenoxypropyonic chloride

: 1451076-36-0
5-allyl-7,7-difluoro-2-(2,4-difluorophenyl)-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-amine

: 1451076-49-5
N-(5-allyl-2-(2,4-difluorophenyl)-7,7-difluoro-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-3-yl)-3-phenoxypropanamide

Guidance literature:: With pyridine; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.tetlet.2013.07.076

Reference yield:

: 1451076-33-7
3-(N-((1H-benzo[d][1,2,3]triazol-1-yl)-(4-methoxyphenyl)methyl)-N-allylamino)propanenitrile

: 1451076-49-5
N-(5-allyl-2-(2,4-difluorophenyl)-7,7-difluoro-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-3-yl)-3-phenoxypropanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: zinc; chloro-trimethyl-silane / tetrahydrofuran / 0.17 h / Inert atmosphere

1.2: 12 h / 20 °C / Inert atmosphere

2.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 13 h / -78 - 20 °C / Inert atmosphere

3.1: ethanol / Reflux; Inert atmosphere

4.1: pyridine / 0 - 20 °C / Inert atmosphere

With pyridine; n-butyllithium; chloro-trimethyl-silane; diisopropylamine; zinc; In tetrahydrofuran; ethanol; hexane; 1.1: |Mannich Aminomethylation / 2.1: |Dieckmann Condensation;
DOI:10.1016/j.tetlet.2013.07.076

Reference yield:

: 1451076-34-8
ethyl 3-(N-(2-cyanoethyl)allylamino)-2,2-difluoro-3-(4-methoxyphenyl)propanoate

: 1451076-49-5
N-(5-allyl-2-(2,4-difluorophenyl)-7,7-difluoro-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-3-yl)-3-phenoxypropanamide

Guidance literature:: Multi-step reaction with 3 steps

1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 13 h / -78 - 20 °C / Inert atmosphere

2: ethanol / Reflux; Inert atmosphere

3: pyridine / 0 - 20 °C / Inert atmosphere

With pyridine; n-butyllithium; diisopropylamine; In tetrahydrofuran; ethanol; hexane; 1: |Dieckmann Condensation;
DOI:10.1016/j.tetlet.2013.07.076