3-(N-((1H-benzo[d][1,2,3]triazol-1-yl)-(4-methoxyphenyl)methyl)-N-allylamino)propanenitrile

Base Information

Chemical Name:3-(N-((1H-benzo[d][1,2,3]triazol-1-yl)-(4-methoxyphenyl)methyl)-N-allylamino)propanenitrile
CAS No.:1451076-33-7
Molecular Formula:C₂₀H₂₁N₅O
Molecular Weight:347.42
Hs Code.:

Synonyms:3-(N-((1H-benzo[d][1,2,3]triazol-1-yl)-(4-methoxyphenyl)methyl)-N-allylamino)propanenitrile

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Chemical Property of 3-(N-((1H-benzo[d][1,2,3]triazol-1-yl)-(4-methoxyphenyl)methyl)-N-allylamino)propanenitrile

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Technology Process of 3-(N-((1H-benzo[d][1,2,3]triazol-1-yl)-(4-methoxyphenyl)methyl)-N-allylamino)propanenitrile

There total 1 articles about 3-(N-((1H-benzo[d][1,2,3]triazol-1-yl)-(4-methoxyphenyl)methyl)-N-allylamino)propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 95-14-7,27556-51-0
1,2,3-Benzotriazole

: 34508-81-1
3-[(prop-2-en-1-yl)amino]propanenitrile

: 123-11-5
4-methoxy-benzaldehyde

: 1451076-33-7
3-(N-((1H-benzo[d][1,2,3]triazol-1-yl)-(4-methoxyphenyl)methyl)-N-allylamino)propanenitrile

Guidance literature:: In methanol; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.tetlet.2013.07.076

Reference yield:

: 1451076-33-7
3-(N-((1H-benzo[d][1,2,3]triazol-1-yl)-(4-methoxyphenyl)methyl)-N-allylamino)propanenitrile

: 1-(5-allyl-2-(2,4-dichlorophenyl)-7,7-difluoro-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-3-yl)-3-cyclohexylthiourea

Guidance literature:: Multi-step reaction with 4 steps

1.1: zinc; chloro-trimethyl-silane / tetrahydrofuran / 0.17 h / Inert atmosphere

1.2: 12 h / 20 °C / Inert atmosphere

2.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 13 h / -78 - 20 °C / Inert atmosphere

3.1: ethanol / Reflux; Inert atmosphere

4.1: pyridine / 0 - 20 °C / Inert atmosphere

With pyridine; n-butyllithium; chloro-trimethyl-silane; diisopropylamine; zinc; In tetrahydrofuran; ethanol; hexane; 1.1: |Mannich Aminomethylation / 2.1: |Dieckmann Condensation;
DOI:10.1016/j.tetlet.2013.07.076

Reference yield:

: 1451076-33-7
3-(N-((1H-benzo[d][1,2,3]triazol-1-yl)-(4-methoxyphenyl)methyl)-N-allylamino)propanenitrile

: 1451076-47-3
N-(5-allyl-2-(2,4-difluorophenyl)-7,7-difluoro-6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: zinc; chloro-trimethyl-silane / tetrahydrofuran / 0.17 h / Inert atmosphere

1.2: 12 h / 20 °C / Inert atmosphere

2.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 13 h / -78 - 20 °C / Inert atmosphere

3.1: ethanol / Reflux; Inert atmosphere

4.1: pyridine / 0 - 20 °C / Inert atmosphere

With pyridine; n-butyllithium; chloro-trimethyl-silane; diisopropylamine; zinc; In tetrahydrofuran; ethanol; hexane; 1.1: |Mannich Aminomethylation / 2.1: |Dieckmann Condensation;
DOI:10.1016/j.tetlet.2013.07.076