(3-{3-[3,5-bis-(2-methyl-pentyloxy)-benzyloxy]-5-bromomethyl-phenoxymethyl}-phenyl)-naphthalen-2-yl-phenyl-amine

Base Information

Chemical Name:(3-{3-[3,5-bis-(2-methyl-pentyloxy)-benzyloxy]-5-bromomethyl-phenoxymethyl}-phenyl)-naphthalen-2-yl-phenyl-amine
CAS No.:636984-56-0
Molecular Formula:C₄₉H₅₄BrNO₄
Molecular Weight:800.876
Hs Code.:

Synonyms:(3-{3-[3,5-bis-(2-methyl-pentyloxy)-benzyloxy]-5-bromomethyl-phenoxymethyl}-phenyl)-naphthalen-2-yl-phenyl-amine

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Chemical Property of (3-{3-[3,5-bis-(2-methyl-pentyloxy)-benzyloxy]-5-bromomethyl-phenoxymethyl}-phenyl)-naphthalen-2-yl-phenyl-amine

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Technology Process of (3-{3-[3,5-bis-(2-methyl-pentyloxy)-benzyloxy]-5-bromomethyl-phenoxymethyl}-phenyl)-naphthalen-2-yl-phenyl-amine

There total 11 articles about (3-{3-[3,5-bis-(2-methyl-pentyloxy)-benzyloxy]-5-bromomethyl-phenoxymethyl}-phenyl)-naphthalen-2-yl-phenyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 636984-55-9
{3-[3,5-bis-(2-methyl-pentyloxy)-benzyloxy]-5-[3-(naphthalen-2-yl-phenyl-amino)-benzyloxy]-phenyl}-methanol

: 636984-56-0
(3-{3-[3,5-bis-(2-methyl-pentyloxy)-benzyloxy]-5-bromomethyl-phenoxymethyl}-phenyl)-naphthalen-2-yl-phenyl-amine

Guidance literature:: With carbon tetrabromide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran;
DOI:10.1021/ja037133f

Reference yield:

: 17100-67-3
2-<(3-bromobenzyl)oxy>tetrahydro-2H-pyran

: 636984-56-0
(3-{3-[3,5-bis-(2-methyl-pentyloxy)-benzyloxy]-5-bromomethyl-phenoxymethyl}-phenyl)-naphthalen-2-yl-phenyl-amine

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / DPPF; NaOt-Bu; Pd₂(dba)3 / toluene / 30 h / 90 °C

2: 89 percent / PPh₃; Br₂ / CH₂Cl₂ / 0.5 h / 20 °C

3: 88 percent / K₂CO₃; 18-crown-6 / acetone / 16 h / 60 °C

4: 98 percent / LAH / tetrahydrofuran / 0.25 h / 0 - 20 °C

5: 93 percent / PPh₃; CBr₄; DIPEA / tetrahydrofuran

With 1,1'-bis-(diphenylphosphino)ferrocene; lithium aluminium tetrahydride; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; 18-crown-6 ether; carbon tetrabromide; bromine; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium t-butanolate; In tetrahydrofuran; dichloromethane; acetone; toluene; 3: Williamson etherification;
DOI:10.1021/ja037133f

Reference yield:

: 105-30-6
2-methylpentan-1-ol

: 636984-56-0
(3-{3-[3,5-bis-(2-methyl-pentyloxy)-benzyloxy]-5-bromomethyl-phenoxymethyl}-phenyl)-naphthalen-2-yl-phenyl-amine

Guidance literature:: Multi-step reaction with 6 steps

1: 73 percent / PPh₃; DEAD / CH₂Cl₂; tetrahydrofuran / 14 h / 20 °C

2: LAH / tetrahydrofuran / 0.25 h / 0 - 20 °C

3: 4.68 g / PPh₃; DIAD / CH₂Cl₂; tetrahydrofuran / 14 h / 20 °C

4: 88 percent / K₂CO₃; 18-crown-6 / acetone / 16 h / 60 °C

5: 98 percent / LAH / tetrahydrofuran / 0.25 h / 0 - 20 °C

6: 93 percent / PPh₃; CBr₄; DIPEA / tetrahydrofuran

With lithium aluminium tetrahydride; 18-crown-6 ether; carbon tetrabromide; di-isopropyl azodicarboxylate; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; acetone; 1: Mitsunobu reaction / 3: Mitsunobu reaction / 4: Williamson etherification;
DOI:10.1021/ja037133f