{3-[3,5-bis-(2-methyl-pentyloxy)-benzyloxy]-5-[3-(naphthalen-2-yl-phenyl-amino)-benzyloxy]-phenyl}-methanol

Base Information

Chemical Name:{3-[3,5-bis-(2-methyl-pentyloxy)-benzyloxy]-5-[3-(naphthalen-2-yl-phenyl-amino)-benzyloxy]-phenyl}-methanol
CAS No.:636984-55-9
Molecular Formula:C₄₉H₅₅NO₅
Molecular Weight:737.979
Hs Code.:

Synonyms:{3-[3,5-bis-(2-methyl-pentyloxy)-benzyloxy]-5-[3-(naphthalen-2-yl-phenyl-amino)-benzyloxy]-phenyl}-methanol

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Chemical Property of {3-[3,5-bis-(2-methyl-pentyloxy)-benzyloxy]-5-[3-(naphthalen-2-yl-phenyl-amino)-benzyloxy]-phenyl}-methanol

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Technology Process of {3-[3,5-bis-(2-methyl-pentyloxy)-benzyloxy]-5-[3-(naphthalen-2-yl-phenyl-amino)-benzyloxy]-phenyl}-methanol

There total 10 articles about {3-[3,5-bis-(2-methyl-pentyloxy)-benzyloxy]-5-[3-(naphthalen-2-yl-phenyl-amino)-benzyloxy]-phenyl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 636984-54-8
3-[3,5-bis-(2-methyl-pentyloxy)-benzyloxy]-5-[3-(naphthalen-2-yl-phenyl-amino)-benzyloxy]-benzoic acid methyl ester

: 636984-55-9
{3-[3,5-bis-(2-methyl-pentyloxy)-benzyloxy]-5-[3-(naphthalen-2-yl-phenyl-amino)-benzyloxy]-phenyl}-methanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.25h;
DOI:10.1021/ja037133f

Reference yield:

: 17100-67-3
2-<(3-bromobenzyl)oxy>tetrahydro-2H-pyran

: 636984-55-9
{3-[3,5-bis-(2-methyl-pentyloxy)-benzyloxy]-5-[3-(naphthalen-2-yl-phenyl-amino)-benzyloxy]-phenyl}-methanol

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / DPPF; NaOt-Bu; Pd₂(dba)3 / toluene / 30 h / 90 °C

2: 89 percent / PPh₃; Br₂ / CH₂Cl₂ / 0.5 h / 20 °C

3: 88 percent / K₂CO₃; 18-crown-6 / acetone / 16 h / 60 °C

4: 98 percent / LAH / tetrahydrofuran / 0.25 h / 0 - 20 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; lithium aluminium tetrahydride; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; 18-crown-6 ether; bromine; potassium carbonate; triphenylphosphine; sodium t-butanolate; In tetrahydrofuran; dichloromethane; acetone; toluene; 3: Williamson etherification;
DOI:10.1021/ja037133f

Reference yield:

: 105-30-6
2-methylpentan-1-ol

: 636984-55-9
{3-[3,5-bis-(2-methyl-pentyloxy)-benzyloxy]-5-[3-(naphthalen-2-yl-phenyl-amino)-benzyloxy]-phenyl}-methanol

Guidance literature:: Multi-step reaction with 5 steps

1: 73 percent / PPh₃; DEAD / CH₂Cl₂; tetrahydrofuran / 14 h / 20 °C

2: LAH / tetrahydrofuran / 0.25 h / 0 - 20 °C

3: 4.68 g / PPh₃; DIAD / CH₂Cl₂; tetrahydrofuran / 14 h / 20 °C

4: 88 percent / K₂CO₃; 18-crown-6 / acetone / 16 h / 60 °C

5: 98 percent / LAH / tetrahydrofuran / 0.25 h / 0 - 20 °C

With lithium aluminium tetrahydride; 18-crown-6 ether; di-isopropyl azodicarboxylate; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; acetone; 1: Mitsunobu reaction / 3: Mitsunobu reaction / 4: Williamson etherification;
DOI:10.1021/ja037133f