4,4’-dimethoxytrityl trifluoromethanesulfonate

Base Information

• Chemical Name: 4,4’-dimethoxytrityl trifluoromethanesulfonate
• CAS No.: 239808-67-4
• Molecular Formula: C₂₂H₁₉F₃O₅S
• Molecular Weight: 452.451
• Mol file: 239808-67-4.mol

Synonyms:4,4’-dimethoxytrityl trifluoromethanesulfonate

Chemical Property of 4,4’-dimethoxytrityl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,4’-dimethoxytrityl trifluoromethanesulfonate

There total 1 articles about 4,4’-dimethoxytrityl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) + silver trifluoromethanesulfonate (2923-28-6) → 4,4’-dimethoxytrityl trifluoromethanesulfonate (239808-67-4)

Guidance literature:

In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/jo051187l

Reference yield: 100.0%

1-((2R,3S,3aS,7aS)-3a-Hydroxy-7a-hydroxymethyl-3-methoxy-hexahydro-furo[2,3-c]pyran-2-yl)-5-methyl-1H-pyrimidine-2,4-dione (583844-12-6) + 4,4’-dimethoxytrityl trifluoromethanesulfonate (239808-67-4) → 1-{(2R,3S,3aS,7aR)-7a-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3a-hydroxy-3-methoxy-hexahydro-furo[2,3-c]pyran-2-yl}-5-methyl-1H-pyrimidine-2,4-dione (583844-13-7)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 5h;

DOI:10.1021/jo051187l

Reference yield: 100.0%

(5R)-N(3)-2-(trimethylsilyl)ethoxymethyl-5'-O-tert-butyldiphenylsilyl-5-(N(3)-2-(trimethylsilyl)ethoxymethyl-3'-O-tert-butyldiphenylsilyl-thymidin-α(5)-yl)-5,6-dihydrothymidine (1072452-77-7) + 4,4’-dimethoxytrityl trifluoromethanesulfonate (239808-67-4) → (5R)-N(3)-2-(trimethylsilyl)ethoxymethyl-5'-O-tert-butyldiphenylsilyl-5-(N(3)-2-(trimethylsilyl)ethoxymethyl-5'-O-dimethoxytrityl-3'-O-tert-butyldiphenylsilyl-thymidin-α(5)-yl)-5,6-dihydrothymidine

Guidance literature:

4,4'-dimethoxytrityl trifluoromethanesulfonate; With pyridine; at 20 ℃; for 3h; Molecular sieve;

(5R)-N(3)-2-(trimethylsilyl)ethoxymethyl-5'-O-tert-butyldiphenylsilyl-5-(N(3)-2-(trimethylsilyl)ethoxymethyl-3'-O-tert-butyldiphenylsilyl-thymidin-α(5)-yl)-5,6-dihydrothymidine; With pyridine; at 20 ℃; for 6h; Molecular sieve;

DOI:10.1039/b810008j

upstream raw materials:

4,4'-dimethoxytrityl chloride

silver trifluoromethanesulfonate

Downstream raw materials:

(3'S,5'R)-1-<2'-deoxy-5'-O-<(4,4'-dimethoxytriphenyl)methyl>-3',5'-ethano-β-D-ribofuranosyl>thymine

(3'S,5'R)-N⁶-benzoyl-9-<2'-deoxy-5'-O-<(4,4'-dimethoxytriphenyl)methyl>-3',5'-ethano-β-D-ribofuranosyl>adenine

(3'S,5'R)-1-<2'-deoxy-5'-O-<(4,4'-dimethoxytriphenyl)methyl>-3',5'-ethano-α-D-ribofuranosyl>thymine

(3'S,5'R)-N⁶-benzoyl-9-<2'-deoxy-5'-O-<(4,4'-dimethoxytriphenyl)methyl>-3',5'-ethano-α-D-ribofuranosyl>adenine