tert-butyl 2-((2R,5S,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl)acetate

Base Information

Chemical Name:tert-butyl 2-((2R,5S,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl)acetate
CAS No.:1429384-30-4
Molecular Formula:C₂₆H₂₉Cl₂NO₄
Molecular Weight:490.427
Hs Code.:

Synonyms:tert-butyl 2-((2R,5S,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl)acetate

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Chemical Property of tert-butyl 2-((2R,5S,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl)acetate

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Technology Process of tert-butyl 2-((2R,5S,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl)acetate

There total 2 articles about tert-butyl 2-((2R,5S,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₁₉Cl₂NO

: 191221-14-4
(S)-2-bromo-3-(tert-butoxycarbonyl)propionic acid

: 1429383-71-0
tert-butyl 2-((2R,5R,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl)acetate

: 1429383-72-1
tert-butyl 2-((2S,5R,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl)acetate

: 1429384-30-4
tert-butyl 2-((2R,5S,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl)acetate

: 1429384-31-5
tert-butyl 2-((2S,5S,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl)acetate

Guidance literature:: C₁₈H₁₉Cl₂NO; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.5h;

(S)-2-bromo-3-(tert-butoxycarbonyl)propionic acid; In tetrahydrofuran; mineral oil; at 20 ℃;

Reference yield:

: 3057-74-7
L-Asp(t-Bu)

: 1429383-71-0
tert-butyl 2-((2R,5R,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl)acetate

: 1429383-72-1
tert-butyl 2-((2S,5R,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl)acetate

: 1429384-30-4
tert-butyl 2-((2R,5S,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl)acetate

: 1429384-31-5
tert-butyl 2-((2S,5S,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-3-oxomorpholin-2-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium nitrite; hydrogen bromide; sodium bromide / water / 0.5 h / -15 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C

2.2: 20 °C

With hydrogen bromide; sodium hydride; sodium bromide; sodium nitrite; In tetrahydrofuran; water; mineral oil;