(Z)-ethyl 5-(2-(benzothiazol-2-yl)-2-oxo-1-(phenylsulfonyl)ethylidene)-4-(4-chlorophenyl)-4,5-dihydro-1,3,4-thiadiazole-2-carboxylate

Base Information

Chemical Name:(Z)-ethyl 5-(2-(benzothiazol-2-yl)-2-oxo-1-(phenylsulfonyl)ethylidene)-4-(4-chlorophenyl)-4,5-dihydro-1,3,4-thiadiazole-2-carboxylate
CAS No.:1634722-68-1
Molecular Formula:C₂₆H₁₈ClN₃O₅S₃
Molecular Weight:584.097
Hs Code.:

Synonyms:(Z)-ethyl 5-(2-(benzothiazol-2-yl)-2-oxo-1-(phenylsulfonyl)ethylidene)-4-(4-chlorophenyl)-4,5-dihydro-1,3,4-thiadiazole-2-carboxylate

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Chemical Property of (Z)-ethyl 5-(2-(benzothiazol-2-yl)-2-oxo-1-(phenylsulfonyl)ethylidene)-4-(4-chlorophenyl)-4,5-dihydro-1,3,4-thiadiazole-2-carboxylate

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Technology Process of (Z)-ethyl 5-(2-(benzothiazol-2-yl)-2-oxo-1-(phenylsulfonyl)ethylidene)-4-(4-chlorophenyl)-4,5-dihydro-1,3,4-thiadiazole-2-carboxylate

There total 3 articles about (Z)-ethyl 5-(2-(benzothiazol-2-yl)-2-oxo-1-(phenylsulfonyl)ethylidene)-4-(4-chlorophenyl)-4,5-dihydro-1,3,4-thiadiazole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1634722-92-1
(Z)-1-(benzothiazol-2-yl)-3-mercapto-3-(phenylamino)-2-(phenylsulfonyl)prop-2-en-1-one

: 27143-09-5,132839-05-5
ethyl 2-chloro[(4-chlorophenyl)hydrazono]acetate

: 1634722-68-1
(Z)-ethyl 5-(2-(benzothiazol-2-yl)-2-oxo-1-(phenylsulfonyl)ethylidene)-4-(4-chlorophenyl)-4,5-dihydro-1,3,4-thiadiazole-2-carboxylate

Guidance literature:: With triethylamine; In ethanol; at 20 ℃; for 12h;
DOI:10.3987/COM-14-13020

Reference yield:

: 1591907-98-0
1-(benzothiazol-2-yl)-2-phenylsulfonyl-1-ethanone

: 1634722-68-1
(Z)-ethyl 5-(2-(benzothiazol-2-yl)-2-oxo-1-(phenylsulfonyl)ethylidene)-4-(4-chlorophenyl)-4,5-dihydro-1,3,4-thiadiazole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 6 h / 20 °C

1.3: Cooling with ice

2.1: triethylamine / ethanol / 12 h / 20 °C

With triethylamine; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.3987/COM-14-13020

Reference yield:

: 103-72-0
phenyl isothiocyanate

: 1634722-68-1
(Z)-ethyl 5-(2-(benzothiazol-2-yl)-2-oxo-1-(phenylsulfonyl)ethylidene)-4-(4-chlorophenyl)-4,5-dihydro-1,3,4-thiadiazole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 6 h / 20 °C

1.3: Cooling with ice

2.1: triethylamine / ethanol / 12 h / 20 °C

With triethylamine; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.3987/COM-14-13020