N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl]-L-valine

Base Information

• Chemical Name: N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl]-L-valine
• CAS No.: 866832-83-9
• Molecular Formula: C₁₅H₂₃NO₄
• Molecular Weight: 281.352
• Mol file: 866832-83-9.mol

Synonyms:N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl]-L-valine

Chemical Property of N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl]-L-valine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl]-L-valine

There total 4 articles about N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl]-L-valine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) + 2-(1-hydroxyethylidene)-5,5-dimethylcyclohexane-1,3-dione (94142-97-9) → N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl]-L-valine (866832-83-9)

Guidance literature:

With triethylamine; In ethanol; for 18h; Heating;

DOI:10.1021/jo050959a

Reference yield: 70.0%

L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) + 2-acetyldimedone (1755-15-3) → N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl]-L-valine (866832-83-9)

Guidance literature:

With triethylamine; In ethanol; for 18h; Reflux;

DOI:10.1021/acs.jmedchem.7b01280

Reference yield:

dimedone (126-81-8) → N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl]-L-valine (866832-83-9)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane / 8 h / 20 °C / Cooling with ice

2: triethylamine / ethanol / 18 h / Reflux

With dmap; triethylamine; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;

DOI:10.1021/acs.jmedchem.7b01280

upstream raw materials:

L-valine

2-(1-hydroxyethylidene)-5,5-dimethylcyclohexane-1,3-dione

2-acetyldimedone

dimedone

Downstream raw materials:

N-(9H-fluoren-9-ylmethoxycarbonyl)-O-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl]-L-valyl}-D-serine benzyl ester