94142-97-9

Usage

Uses

Used in Environmental Monitoring and Research:
DDE-OH is used as a biomarker for monitoring the presence and impact of DDT and its derivatives in the environment. It helps researchers understand the extent of environmental contamination and the potential risks associated with exposure to these chemicals.
Used in Toxicological Studies:
DDE-OH is used as a subject in toxicological studies to investigate its potential adverse health effects, including reproductive and developmental abnormalities, as well as its association with certain types of cancer. These studies contribute to the development of regulations and guidelines for the safe use of pesticides and their derivatives.
Used in Regulatory Frameworks:
DDE-OH is used as a reference substance in the development of regulatory frameworks to control the use and disposal of DDT and its derivatives. By setting limits on the acceptable levels of DDE-OH in the environment, regulatory bodies aim to minimize the potential health risks and environmental impact of these chemicals.
Used in Public Health Awareness:
DDE-OH is used as a case study in public health awareness campaigns to educate the public about the potential risks associated with exposure to DDT and its derivatives. By raising awareness about the presence of DDE-OH in the environment and its potential health effects, these campaigns aim to promote safer practices and encourage the adoption of alternative pest control methods.

InChI:InChI=1/C10H14O3/c1-6(11)9-7(12)4-10(2,3)5-8(9)13/h9,11H,1,4-5H2,2-3H3

Upstream product

• 126-81-8 dimedone 
• 64-19-7 acetic acid 
• 75-36-5 acetyl chloride 

Downstream Products

• 18930-29-5 5,5-dimethyl-2-<1-(pyrrolidino)ethylidene>cyclohexane-1,3-dione 
• 150629-67-7 Fmoc-Lys(Dde)-OH 
• 267410-80-0 C₃₀H₅₀N₄O₄ 
• 302916-24-1 4-{N-(2,4-dimethoxybenzyl)-N'-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl]hydrazino}benzoic acid 
• 727720-13-0 3-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethylamino]pyrrolidine 
• 869735-81-9 {2-[1-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-ethylamino]-ethyl}-carbamic acid tert-butyl ester 
• 864776-37-4 {{2-[1-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-ethylamino]-ethyl}-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetic acid methyl ester 
• 682753-04-4 N-[2-(thymin-1-yl)-acetyl]-N-{2-[1-(4,4-dimethyl-2,6-dioxo-cyclohexyliden)-ethylamino]-ethyl}glycine 
• 864776-35-2 methyl N-{2-[N'⁴-(4-methoxytrityl)-cytosin-1-yl]-acetyl}-N-{2-[1-(4,4-dimethyl-2,6-dioxo-cyclohexyliden)ethylamino]ethyl}glycinate 
• 682752-98-3 N-{2-[N'⁴-(4-methoxytrityl)-cytosin-1-yl]-acetyl}-N-{2-[1-(4,4-dimethyl-2,6-dioxo-cyclohexyliden)ethylamino]ethyl}glycine 
• 864776-34-1 methyl N-{2-[N'⁶-(4-methoxytrityl)-adenin-9-yl]-acetyl}-N-{2-[1-(4,4-dimethyl-2,6-dioxo-cyclohexyliden)ethylamino]ethyl}glycinate 
• 682753-01-1 N-{2-[N'⁶-(4-methoxytrityl)-adenin-9-yl]-acetyl}-N-{2-[1-(4,4-dimethyl-2,6-dioxo-cyclohexyliden)ethylamino]ethyl}glycine 
• 682752-95-0 {{2-[1-(4,4-Dimethyl-2,6-dioxo-cyclohexylidene)-ethylamino]-ethyl}-[2-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-6-oxo-1,6-dihydro-purin-9-yl)-acetyl]-amino}-acetic acid 
• 864776-36-3 {{2-[1-(4,4-Dimethyl-2,6-dioxo-cyclohexylidene)-ethylamino]-ethyl}-[2-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-6-oxo-1,6-dihydro-purin-9-yl)-acetyl]-amino}-acetic acid methyl ester 

Relevant academic research and scientific papers

Total and Semisyntheses of Polymyxin Analogues with 2-Thr or 10-Thr Modifications to Decipher the Structure-Activity Relationship and Improve the Antibacterial Activity

Herein, we report the total and semisyntheses of a series of polymyxin analogues with 2-Thr and 10-Thr modifications to reveal the structure-activity relationship (SAR), which has not been fully elucidated previously. We employed two total-synthetic strategies to facilitate the diversified replacements on 2-Thr or 10-Thr, respectively. Moreover, semisynthetic approaches were utilized to achieve selective esterification of 2-Thr or dual esterification of both 2- and 10-Thr. Based on the results of in vitro antibacterial assays, SAR analysis implicated that the replacement of 2-/10-Thr with amino acids carrying hydrophobic side chains can maintain the activity against Pseudomonas aeruginosa but had varied effects on other tested Gram-negative bacteria. The aminoacetyl esterification on 2-/10-Thr achieved excellent antibacterial activity, and the compound 76 exhibited 2-8-fold higher activity against different strains and lower toxicity toward the HK-2 cell line. This work explored the SAR of polymyxin 2-/10-Thr and provided a promising strategy for the development of novel polymyxin derivatives.

Preparation method of N alpha-fluorenylmethoxycarbonyl-N gamma-(4, 4-dimethyl-2,6-dioxocyclohexylidene) ethyl-butyric acid

The invention provides a preparation method of (2S)-4-[[1-(4,4-dimethyl-2,6-dioxocyclohexylidene) ethyl] amino]-2-[[(9H-fluoren-9-ylmethoxy) carbonyl] amino] butyric acid, and mainly solves the technical problems that an existing preparation method is com

Activation of lysine-specific demethylase 1 inhibitor peptide by redox-controlled cleavage of a traceless linker

We have previously employed cyclization of a linear peptide as a strategy to modulate peptide function and properties, but cleavage to regenerate the linear peptide left parts of the linker structure on the peptide, interfering with its activity. Here, we focused on cyclization of a linear peptide via a “traceless” disulfide-based linkage that would be cleaved and completely removed in a reducing environment, regenerating the original linear peptide without any linker-related structure. Thus, the linker would serve as a redox switch that would be activated in the intracellular environment. We applied this strategy to a lysine-specific demethylase 1 (LSD1) inhibitor peptide 1. The resulting cyclic peptide 2 exhibited approximately 20 times weaker LSD1-inhibitory activity than peptide 1. Upon addition of reducing reagent, the linker was completely removed to regenerate the linear peptide 1, with full restoration of the LSD1-inhibitory activity. In addition, the cyclic peptide was far less susceptible to proteolysis than the linear counterpart. Thus, this switch design not only enables control of functional activity, but also improves stability. This approach should be applicable to a wide range of peptides, and may be useful in the development of peptide pharmaceuticals.

OPTICAL IMAGING PROBES

The present invention relates to methods of visualising cells especially although not exclusively in vivo using a dye, such as a dendrimer-dye molecule or polybranched-dye molecule which is internalised by the cells and thus permits subsequent visualisation by confocal fluorescence endomicroscopy or other optical detectors. There is also provided internally quenched probes for use in visualising cells especially although not exclusively in vivo by confocal fluorescence endomicroscopy and the use of internally quenched probes in combination with confocal fluorescence endomicroscopy, for visualising cells by virtue of internalisation and dequenching of a probe by the cells. In a particular embodiment the cells are activated neutrophils, such as within the lung of a subject.

Solid-phase synthesis of C-terminal peptide libraries for studying the specificity of enzymatic protein prenylation

Prenylation is an essential post-translational modification in all eukaryotes. Here we describe the synthesis of a 340-member library of peptides containing free C-termini on cellulose membranes. The resulting library was then used to probe the specificit

Introduction of functional groups into peptides via N-alkylation

An optimized protocol for the mild and selective Fukuyama-Mitsunobu reaction was used for mono- and di-N-alkylation on solid support. Thereby, nonfunctionalized aliphatic and aromatic residues are quickly introduced into transiently protected, primary ami

An appraisal of new variants of Dde amine protecting group for solid phase peptide synthesis

A series of new variants of Dde, substituted at the exocyclic alkene position have been developed and their application in solid phase peptide synthesis assessed. The new derivatives offer complete resistance towards 20% piperidine in DMF and provide a considerable barrier towards N→N'-intramolecular migration.