2,5-Dimethylthiophene-3-boronic acid

Base Information

Chemical Name:2,5-Dimethylthiophene-3-boronic acid
CAS No.:162607-23-0
Molecular Formula:C6H9BO2S
Molecular Weight:156.013
Hs Code.:2934999090
Mol file:162607-23-0.mol

Synonyms:2,5-Dimethyl-3-thienylboronic acid;Boronicacid, (2,5-dimethyl-3-thienyl)- (9CI);

Suppliers and Price of 2,5-Dimethylthiophene-3-boronic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2,5-Dimethylthiophene-3-boronicAcid
250mg
$ 195.00

SynQuest Laboratories
2,5-Dimethylthiophene-3-boronic acid
250 mg
$ 165.00

SynQuest Laboratories
2,5-Dimethylthiophene-3-boronic acid
100 mg
$ 65.00

SynQuest Laboratories
2,5-Dimethylthiophene-3-boronic acid
1 g
$ 295.00

Crysdot
(2,5-Dimethylthiophen-3-yl)boronicacid 95+%
5g
$ 684.00

Chemenu
(2,5-Dimethylthiophen-3-yl)boronicacid 95%
5g
$ 705.00

Biosynth Carbosynth
2,5-Dimethylthiophene-3-boronic acid
1 g
$ 400.00

Biosynth Carbosynth
2,5-Dimethylthiophene-3-boronic acid
50 mg
$ 70.00

Biosynth Carbosynth
2,5-Dimethylthiophene-3-boronic acid
100 mg
$ 110.00

Biosynth Carbosynth
2,5-Dimethylthiophene-3-boronic acid
500 mg
$ 300.00

Total 24 raw suppliers

Chemical Property of 2,5-Dimethylthiophene-3-boronic acid

Chemical Property:

Vapor Pressure:0.000241mmHg at 25°C
Melting Point:180-183 °C
Refractive Index:1.542
Boiling Point:311.4 °C at 760 mmHg
PKA:8.42±0.58(Predicted)
Flash Point:142.2 °C
PSA：68.70000
Density:1.2g/cm³
LogP:0.04470
Storage Temp.:Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
Solubility.:Chloroform (Sparingly), DMSO (Slightly, Heated)

Purity/Quality:

97% ^*data from raw suppliers

2,5-Dimethylthiophene-3-boronicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 2,5-Dimethylthiophene-3-boronic Acid can be used KRAS G12C inhibitors to treat a number of disorders, including pancreatic, colorectal, and lung cancers.

Technology Process of 2,5-Dimethylthiophene-3-boronic acid

There total 10 articles about 2,5-Dimethylthiophene-3-boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 40197-02-2
3-iodo-2,5-dimethylthiophene

: 122-56-5
tributyl borane

: 1310-73-2
sodium hydroxide

: 162607-23-0
2,5-dimethylthien-3-ylboronic acid

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; soln. of n-BuLi in hexane added at -78°C under Ar to soln. of C4HSMe2I on THF; react. mixt. stirred at this temp. for 30 min and Bu3B then added with additional stirring for 1 h; mixt. slow heated, cooled to 0°C ...; NaOH added ...; ppt. filtered off, washed with small amt. and dried in desiccator; elem.anal.;
DOI:10.1007/s11172-005-0126-6

Reference yield: 73.0%

: 31819-37-1
3-bromo-2,5-dimethylthiophene

: 688-74-4
boric acid tributyl ester

: 162607-23-0
2,5-dimethylthien-3-ylboronic acid

Guidance literature:: 3-bromo-2,5-dimethylthiophene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h;

boric acid tributyl ester; In tetrahydrofuran; hexane; at 20 ℃; for 8h;

With hydrogenchloride; In tetrahydrofuran; hexane; water; for 10h;
DOI:10.1007/s11426-020-9874-6

Reference yield:

: 31819-37-1
3-bromo-2,5-dimethylthiophene

: 162607-23-0
2,5-dimethylthien-3-ylboronic acid

Guidance literature:: 3-bromo-2,5-dimethylthiophene; With n-butyllithium; In tetrahydrofuran;

With boric acid tributyl ester;

With hydrogenchloride;