5-(3-ethyl-6-hydroxy-1H-indazol-5-yl)-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazole-3-carboxylic acid cyclopropylamide

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Chemical Name:5-(3-ethyl-6-hydroxy-1H-indazol-5-yl)-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazole-3-carboxylic acid cyclopropylamide
CAS No.:1464138-32-6
Molecular Formula:C₂₅H₂₇N₇O₃
Molecular Weight:473.534
Hs Code.:

Synonyms:5-(3-ethyl-6-hydroxy-1H-indazol-5-yl)-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazole-3-carboxylic acid cyclopropylamide

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Chemical Property of 5-(3-ethyl-6-hydroxy-1H-indazol-5-yl)-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazole-3-carboxylic acid cyclopropylamide

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Technology Process of 5-(3-ethyl-6-hydroxy-1H-indazol-5-yl)-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazole-3-carboxylic acid cyclopropylamide

There total 10 articles about 5-(3-ethyl-6-hydroxy-1H-indazol-5-yl)-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazole-3-carboxylic acid cyclopropylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1464139-80-7
5-(6-benzyloxy-3-ethyl-1H-indazol-5-yl)-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazole carboxylic acid cyclopropylamide

: 1464138-32-6
5-(3-ethyl-6-hydroxy-1H-indazol-5-yl)-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazole-3-carboxylic acid cyclopropylamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol;

Reference yield:

: 392-04-1
methyl 4-fluoro-2-hydroxybenzoate

: 1464138-32-6
5-(3-ethyl-6-hydroxy-1H-indazol-5-yl)-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazole-3-carboxylic acid cyclopropylamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: aluminum (III) chloride / dichloromethane / 0.08 h

1.2: Reflux

2.1: sodium carbonate / N,N-dimethyl-formamide / 60 °C

3.1: hydrazine / tetrahydrofuran

4.1: water; sodium hydroxide / tetrahydrofuran / Reflux

5.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / Cooling with ice

7.1: Lawessons reagent / toluene / 1 h / Reflux

8.1: hydrazine / 1,4-dioxane / 0.5 h / Reflux

9.1: acetic acid / ethanol / Reflux

10.1: palladium 10% on activated carbon; hydrogen / methanol

With Lawessons reagent; aluminum (III) chloride; oxalyl dichloride; palladium 10% on activated carbon; water; hydrogen; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; sodium hydroxide; hydrazine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1464139-72-7
4-fluoro-2-hydroxy-5-propionyl-benzoic acid methyl ester

: 1464138-32-6
5-(3-ethyl-6-hydroxy-1H-indazol-5-yl)-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazole-3-carboxylic acid cyclopropylamide

Guidance literature:: Multi-step reaction with 8 steps

1: sodium carbonate / N,N-dimethyl-formamide / 60 °C

2: hydrazine / tetrahydrofuran

3: water; sodium hydroxide / tetrahydrofuran / Reflux

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / N,N-dimethyl-formamide

5: Lawessons reagent / toluene / 1 h / Reflux

6: hydrazine / 1,4-dioxane / 0.5 h / Reflux

7: acetic acid / ethanol / Reflux

8: palladium 10% on activated carbon; hydrogen / methanol

With Lawessons reagent; dmap; palladium 10% on activated carbon; water; hydrogen; sodium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; hydrazine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide; toluene;