5-(6-benzyloxy-3-ethyl-1H-indazol-5-yl)-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazole carboxylic acid cyclopropylamide

Base Information

Chemical Name:5-(6-benzyloxy-3-ethyl-1H-indazol-5-yl)-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazole carboxylic acid cyclopropylamide
CAS No.:1464139-80-7
Molecular Formula:C₃₂H₃₃N₇O₃
Molecular Weight:563.659
Hs Code.:

Synonyms:5-(6-benzyloxy-3-ethyl-1H-indazol-5-yl)-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazole carboxylic acid cyclopropylamide

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Chemical Property of 5-(6-benzyloxy-3-ethyl-1H-indazol-5-yl)-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazole carboxylic acid cyclopropylamide

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Technology Process of 5-(6-benzyloxy-3-ethyl-1H-indazol-5-yl)-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazole carboxylic acid cyclopropylamide

There total 9 articles about 5-(6-benzyloxy-3-ethyl-1H-indazol-5-yl)-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazole carboxylic acid cyclopropylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1464139-78-3
6-benzyloxy-3-ethyl-1H-indazole-5-carboxylic acid (4-morpholin-4-yl-phenyl)-N-amino-amidine

: 722486-66-0
2-(cyclopropylamino)-2-oxoacetic acid ethyl ester

: 1464139-80-7
5-(6-benzyloxy-3-ethyl-1H-indazol-5-yl)-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazole carboxylic acid cyclopropylamide

Guidance literature:: With acetic acid; In ethanol; Reflux;

Reference yield:

: 392-04-1
methyl 4-fluoro-2-hydroxybenzoate

: 1464139-80-7
5-(6-benzyloxy-3-ethyl-1H-indazol-5-yl)-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazole carboxylic acid cyclopropylamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: aluminum (III) chloride / dichloromethane / 0.08 h

1.2: Reflux

2.1: sodium carbonate / N,N-dimethyl-formamide / 60 °C

3.1: hydrazine / tetrahydrofuran

4.1: water; sodium hydroxide / tetrahydrofuran / Reflux

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / N,N-dimethyl-formamide

6.1: Lawessons reagent / toluene / 1 h / Reflux

7.1: hydrazine / 1,4-dioxane / 0.5 h / Reflux

8.1: acetic acid / ethanol / Reflux

With Lawessons reagent; dmap; aluminum (III) chloride; water; sodium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; hydrazine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1464139-72-7
4-fluoro-2-hydroxy-5-propionyl-benzoic acid methyl ester

: 1464139-80-7
5-(6-benzyloxy-3-ethyl-1H-indazol-5-yl)-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazole carboxylic acid cyclopropylamide

Guidance literature:: Multi-step reaction with 7 steps

1: sodium carbonate / N,N-dimethyl-formamide / 60 °C

2: hydrazine / tetrahydrofuran

3: water; sodium hydroxide / tetrahydrofuran / Reflux

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / N,N-dimethyl-formamide

5: Lawessons reagent / toluene / 1 h / Reflux

6: hydrazine / 1,4-dioxane / 0.5 h / Reflux

7: acetic acid / ethanol / Reflux

With Lawessons reagent; dmap; water; sodium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; hydrazine; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide; toluene;