(R)-diethyl N-benzyloxycarbonyl-2-amino-1,1-difluoro-2-phenylethylphosphonate

Base Information

Chemical Name:(R)-diethyl N-benzyloxycarbonyl-2-amino-1,1-difluoro-2-phenylethylphosphonate
CAS No.:913625-50-0
Molecular Formula:C₂₀H₂₄F₂NO₅P
Molecular Weight:427.385
Hs Code.:

Synonyms:(R)-diethyl N-benzyloxycarbonyl-2-amino-1,1-difluoro-2-phenylethylphosphonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-diethyl N-benzyloxycarbonyl-2-amino-1,1-difluoro-2-phenylethylphosphonate

Chemical Property:

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Technology Process of (R)-diethyl N-benzyloxycarbonyl-2-amino-1,1-difluoro-2-phenylethylphosphonate

There total 4 articles about (R)-diethyl N-benzyloxycarbonyl-2-amino-1,1-difluoro-2-phenylethylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 769195-94-0
(R)-β-amino-α,α-difluoromethylphosphonate

: 913625-50-0
(R)-diethyl N-benzyloxycarbonyl-2-amino-1,1-difluoro-2-phenylethylphosphonate

Guidance literature:: With potassium carbonate; In tetrahydrofuran; water; at 0 - 20 ℃;
DOI:10.1016/j.tet.2006.08.017

Reference yield:

: 1478-53-1
Diethyl difluoromethylphosphonate

: 913625-50-0
(R)-diethyl N-benzyloxycarbonyl-2-amino-1,1-difluoro-2-phenylethylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: LDA / tetrahydrofuran / -78 °C

1.2: 74 percent / tetrahydrofuran / 1 h / -78 °C

2.1: 92 percent / trifluoroacetic acid / ethanol / 0 - 20 °C

3.1: 91 percent / potassium carbonate / tetrahydrofuran; H₂O / 0 - 20 °C

With potassium carbonate; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol; water;
DOI:10.1016/j.tet.2006.08.017

Reference yield:

: 350479-90-2
(S,E)-N-benzylidene-4-methylbenzenesulfinamide

: 913625-50-0
(R)-diethyl N-benzyloxycarbonyl-2-amino-1,1-difluoro-2-phenylethylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: LDA / tetrahydrofuran / -78 °C

1.2: 74 percent / tetrahydrofuran / 1 h / -78 °C

2.1: 92 percent / trifluoroacetic acid / ethanol / 0 - 20 °C

3.1: 91 percent / potassium carbonate / tetrahydrofuran; H₂O / 0 - 20 °C

With potassium carbonate; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol; water;
DOI:10.1016/j.tet.2006.08.017