(R)-monoethyl N-benzyloxycarbonyl-2-amino-1,1-difluoro-2-phenylethylphosphonate

Base Information

Chemical Name:(R)-monoethyl N-benzyloxycarbonyl-2-amino-1,1-difluoro-2-phenylethylphosphonate
CAS No.:913625-52-2
Molecular Formula:C₁₈H₂₀F₂NO₅P
Molecular Weight:399.331
Hs Code.:

Synonyms:(R)-monoethyl N-benzyloxycarbonyl-2-amino-1,1-difluoro-2-phenylethylphosphonate

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Chemical Property of (R)-monoethyl N-benzyloxycarbonyl-2-amino-1,1-difluoro-2-phenylethylphosphonate

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Technology Process of (R)-monoethyl N-benzyloxycarbonyl-2-amino-1,1-difluoro-2-phenylethylphosphonate

There total 5 articles about (R)-monoethyl N-benzyloxycarbonyl-2-amino-1,1-difluoro-2-phenylethylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 913625-50-0
(R)-diethyl N-benzyloxycarbonyl-2-amino-1,1-difluoro-2-phenylethylphosphonate

: 913625-52-2
(R)-monoethyl N-benzyloxycarbonyl-2-amino-1,1-difluoro-2-phenylethylphosphonate

Guidance literature:: With sodium iodide; In acetone; for 6h; Heating;
DOI:10.1016/j.tet.2006.08.017

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 913625-52-2
(R)-monoethyl N-benzyloxycarbonyl-2-amino-1,1-difluoro-2-phenylethylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / potassium carbonate / tetrahydrofuran; H₂O / 0 - 20 °C

2: 75 percent / sodium iodide / acetone / 6 h / Heating

With potassium carbonate; sodium iodide; In tetrahydrofuran; water; acetone;
DOI:10.1016/j.tet.2006.08.017

Reference yield:

: 350479-90-2
(S,E)-N-benzylidene-4-methylbenzenesulfinamide

: 913625-52-2
(R)-monoethyl N-benzyloxycarbonyl-2-amino-1,1-difluoro-2-phenylethylphosphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: LDA / tetrahydrofuran / -78 °C

1.2: 74 percent / tetrahydrofuran / 1 h / -78 °C

2.1: 92 percent / trifluoroacetic acid / ethanol / 0 - 20 °C

3.1: 91 percent / potassium carbonate / tetrahydrofuran; H₂O / 0 - 20 °C

4.1: 75 percent / sodium iodide / acetone / 6 h / Heating

With potassium carbonate; trifluoroacetic acid; sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; ethanol; water; acetone;
DOI:10.1016/j.tet.2006.08.017