Furo[3,2-b]pyridine-2-methanol(9CI)

Base Information

• Chemical Name: Furo[3,2-b]pyridine-2-methanol(9CI)
• CAS No.: 162537-61-3
• Molecular Formula: C₈H₇NO₂
• Molecular Weight: 149.149
• Hs Code.: 2934999090
• Mol file: 162537-61-3.mol

Synonyms:Furo[3,2-b]pyridine-2-methanol (9CI);

Chemical Property of Furo[3,2-b]pyridine-2-methanol(9CI)

Chemical Property:

• Boiling Point: 289.5 °C at 760 mmHg
• Flash Point: 128.9 °C
• PSA: 46.26000
• Density: 1.315 g/cm³
• LogP: 1.32010

Purity/Quality:

97% ^*data from raw suppliers

Furo[3,2-b]pyridin-2-ylmethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Furo[3,2-b]pyridine-2-methanol(9CI)

There total 1 articles about Furo[3,2-b]pyridine-2-methanol(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-iodo-3-hydroxypyridine (40263-57-8) + propargyl alcohol (107-19-7) → furo[3,2-b]pyridin-2-ylmethanol (162537-61-3)

Guidance literature:

With piperidine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In N,N-dimethyl-formamide; at 60 ℃; Inert atmosphere;

DOI:10.1002/adsc.201200543

Reference yield: 62.0%

furo[3,2-b]pyridin-2-ylmethanol (162537-61-3) → 2-formylfuro<3,2-b>pyridine (112372-05-1)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; Sonication; Inert atmosphere;

DOI:10.1002/adsc.201200543

Reference yield:

furo[3,2-b]pyridin-2-ylmethanol (162537-61-3) → 2-cyanofuro<3,2-b>pyridine (112372-11-9)

Guidance literature:

Multi-step reaction with 2 steps

1: manganese(IV) oxide / dichloromethane / Sonication; Inert atmosphere

2: hydroxylamine hydrochloride / pyridine; acetic anhydride / 100 °C

With manganese(IV) oxide; hydroxylamine hydrochloride; In pyridine; dichloromethane; acetic anhydride;

DOI:10.1002/adsc.201200543

upstream raw materials:

2-iodo-3-hydroxypyridine

propargyl alcohol

Downstream raw materials:

2-formylfuro<3,2-b>pyridine

2-cyanofuro<3,2-b>pyridine