2-Iodopyridin-3-ol

Base Information

• Chemical Name: 2-Iodopyridin-3-ol
• CAS No.: 40263-57-8
• Molecular Formula: C5H4INO
• Molecular Weight: 220.997
• Hs Code.: 2933399090
• European Community (EC) Number: 254-864-0
• NSC Number: 103161
• DSSTox Substance ID: DTXSID50193254
• Nikkaji Number: J149.903C
• Wikidata: Q72483654
• Mol file: 40263-57-8.mol

Synonyms:2-Iodopyridin-3-ol;40263-57-8;2-Iodo-3-hydroxypyridine;3-Hydroxy-2-iodopyridine;2-Iodo-3-pyridinol;3-Pyridinol, 2-iodo-;C5H4INO;MFCD00023421;EINECS 254-864-0;2-Iodo-pyridin-3-ol;NSC103161;2-Iodopyridine-3-ol;2-iodo-3-hydroxypyridin;2-iodo-3-hydroxy-pyridine;SCHEMBL531598;Pyridine, 2-iodo-3-hydroxy-;C5-H4-I-N-O;HJBGMPCMSWJZNH-UHFFFAOYSA-;DTXSID50193254;2-Iodo-3-hydroxypyridine, 97%;BCP22989;CCG-2074;CS-D1763;AKOS005258009;AC-6250;MB00322;NSC 103161;NSC-103161;PS-4361;SY015100;AM20070142;EU-0073861;FT-0615803;FT-0647107;H1396;EN300-101423;AC-907/30003006;SR-01000453785;SR-01000453785-1;W-206374

Chemical Property of 2-Iodopyridin-3-ol

Chemical Property:

• Appearance/Colour: WHITE TO TAN SOLID, POWDER, CRYSTALS,CRYSTALLINE POWDER AND/OR CHUNKS
• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 193-195 °C
• Refractive Index: 1.683
• Boiling Point: 296.603 °C at 760 mmHg
• PKA: 4.74±0.10(Predicted)
• Flash Point: 133.181 °C
• PSA: 33.12000
• Density: 2.142 g/cm³
• LogP: 1.39180
• Storage Temp.: Room temperature.
• Sensitive.: Light Sensitive
• Water Solubility.: Slightly soluble in water.
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 220.93376
• Heavy Atom Count: 8
• Complexity: 78.8

Purity/Quality:

99% ^*data from raw suppliers

3-Hydroxy-2-iodopyridine >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-41-37/38-22
• Safety Statements: 26-36-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(N=C1)I)O
• Uses: 2-Iodo-3-hydroxypyridine acts as a reagent in the synthesis of the differentiating antibiotic azatyrosine

Technology Process of 2-Iodopyridin-3-ol

There total 6 articles about 2-Iodopyridin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-HYDROXYPYRIDINE (109-00-2) → 2-iodo-3-hydroxypyridine (40263-57-8)

Guidance literature:

With iodine; sodium carbonate; In water; at 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2011.12.042

Reference yield: 80.0%

3-HYDROXYPYRIDINE (109-00-2) → 2-iodo-3-hydroxypyridine (40263-57-8) + 2,6-diiodo-3-hydroxypyridine (14764-90-0) + 3-hydroxy-2,4,6-triiodopyridine (67868-14-8)

Guidance literature:

With iodine; sodium carbonate; In water; at 20 ℃; for 0.5h; Yields of byproduct given;

DOI:10.1055/s-1990-26918

Reference yield:

3-HYDROXYPYRIDINE (109-00-2) → 2-iodo-3-hydroxypyridine (40263-57-8) + 3-hydroxy-4-iodopyridine (188057-20-7)

Guidance literature:

With sodium hydroxide; sodium hypochlorite; sodium iodide; In methanol; for 5h;

upstream raw materials:

3-HYDROXYPYRIDINE

Downstream raw materials:

1,6-diazaphenodioxin

[2,2'-bipyridine]-3,3'-diol

2-iodo-3-methoxy-pyridine

2-phenylfuro<3,2-b>pyridine

Refernces

• 1、 Yoshida, Atsushi,Ikeshita, Masahiro,Komiya, Naruyoshi,Naota, Takeshi. "Solid-state fluorescence of zwitterionic imidazolium pyridinolates bearing long alkyl chains: Control of emission properties based on variation of lamellar alignment". . p. 6000 - 6007. Retrieved 2017.
• 2、 -. "INHIBITORS OF THE KYNURENINE PATHWAY". Page/Page column 199; 200. . Retrieved 2014/12/12.