Cyclopentanecarboxylic acid, 1-methyl-2-oxo-, methyl ester, (1R)- (9CI)

Base Information

• Chemical Name: Cyclopentanecarboxylic acid, 1-methyl-2-oxo-, methyl ester, (1R)- (9CI)
• CAS No.: 162489-18-1
• Molecular Formula: C₈H₁₂O₃
• Molecular Weight: 156.181
• Mol file: 162489-18-1.mol

Synonyms:Cyclopentanecarboxylicacid, 1-methyl-2-oxo-, methyl ester, (R)-

Chemical Property of Cyclopentanecarboxylic acid, 1-methyl-2-oxo-, methyl ester, (1R)- (9CI)

Chemical Property:

• Vapor Pressure: 0.171mmHg at 25°C
• Refractive Index: 1.46
• Boiling Point: 212.7°Cat760mmHg
• Flash Point: 84.4°C
• PSA: 43.37000
• Density: 1.105g/cm³
• LogP: 0.91870

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclopentanecarboxylic acid, 1-methyl-2-oxo-, methyl ester, (1R)- (9CI)

There total 14 articles about Cyclopentanecarboxylic acid, 1-methyl-2-oxo-, methyl ester, (1R)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methyl (1R,2S)-2-hydroxy-1-methylcyclopentanecarboxylate (122331-04-8,172825-20-6,172825-21-7) → methyl (R)-1-methyl-2-oxocyclopentanecarboxylate (162489-18-1)

Guidance literature:

With chromic acid;

DOI:10.1246/cl.1988.1739

Reference yield: 70.0%

methyl 1-methyl-2-oxocyclopentane-1-carboxylate (30680-84-3) → methyl (R)-1-methyl-2-oxocyclopentanecarboxylate (162489-18-1)

Guidance literature:

DOI:10.1021/jo951206z

Reference yield: 40.0%

N-(2-carbomethoxy-1-cyclopenten-1-yl)-(S)-valine tert-butyl ester (138200-47-2) + methyl iodide (74-88-4) → methyl (R)-1-methyl-2-oxocyclopentanecarboxylate (162489-18-1)

Guidance literature:

N-(2-carbomethoxy-1-cyclopenten-1-yl)-(S)-valine tert-butyl ester; With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide; In hexane; toluene; at -78 ℃; for 0.5h;

methyl iodide; In hexane; toluene; at -25 ℃; for 5h;

With hydrogenchloride; In hexane; water; toluene; at 0 ℃; for 0.5h;

DOI:10.1016/S0040-4020(01)00631-7

upstream raw materials:

methyl (1R)-2-<(2R,3R)-3-hydroxybutan-2-yl>oxy-1-methyl-2-cyclopenten-1-carboxylate

methyl (1R,2S)-2-hydroxy-1-methylcyclopentanecarboxylate

methyl 1-methyl-2-oxocyclopentane-1-carboxylate

N-(2-carbomethoxy-1-cyclopenten-1-yl)-(S)-valine tert-butyl ester

Downstream raw materials:

4-methyl-2-[(1S)-1,2,2-trimethylcyclopentyl]phenol

(S)-5-methyl-3-(1,2,2-trimethylcyclopentyl)benzene-1,2-diol

(-)-mastigophorene B

(1S)-1,2,2-trimethyl-1-(2-methoxy-5-methyl)phenylcyclopentane