1-(2-benzofuranylmethyl)-4-[4-(3-methoxyphenyl)butyl]piperazine

Base Information

• Chemical Name: 1-(2-benzofuranylmethyl)-4-[4-(3-methoxyphenyl)butyl]piperazine
• CAS No.: 1337989-68-0
• Molecular Formula: C₂₄H₃₀N₂O₂
• Molecular Weight: 378.514
• Mol file: 1337989-68-0.mol

Synonyms:1-(2-benzofuranylmethyl)-4-[4-(3-methoxyphenyl)butyl]piperazine

Chemical Property of 1-(2-benzofuranylmethyl)-4-[4-(3-methoxyphenyl)butyl]piperazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-benzofuranylmethyl)-4-[4-(3-methoxyphenyl)butyl]piperazine

There total 4 articles about 1-(2-benzofuranylmethyl)-4-[4-(3-methoxyphenyl)butyl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

N-((benzofuran-2-yl)methyl)piperazine + 1-bromo-4-(3-methoxyphenyl)butane (23464-42-8) → 1-(2-benzofuranylmethyl)-4-[4-(3-methoxyphenyl)butyl]piperazine (1337989-68-0)

Guidance literature:

With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 20h; Reflux; Inert atmosphere;

DOI:10.1016/j.bmcl.2011.08.029

Reference yield:

3-methoxy-1-iodobenzene (766-85-8) → 1-(2-benzofuranylmethyl)-4-[4-(3-methoxyphenyl)butyl]piperazine (1337989-68-0)

Guidance literature:

Multi-step reaction with 4 steps

1: copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; triethylamine / 24 h / 0 °C / Inert atmosphere; Reflux

2: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C / Inert atmosphere

3: carbon tetrabromide; triphenylphosphine / diethyl ether / 16 h / 20 °C / Inert atmosphere

4: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 20 h / 20 °C / Reflux; Inert atmosphere

With copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; carbon tetrabromide; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; triphenylphosphine; sodium iodide; In methanol; diethyl ether; N,N-dimethyl-formamide; 1: Sonogashira coupling / 3: Appel reaction;

DOI:10.1016/j.bmcl.2011.08.029

Reference yield:

4-(3-methoxyphenyl)butan-1-ol (104174-43-8) → 1-(2-benzofuranylmethyl)-4-[4-(3-methoxyphenyl)butyl]piperazine (1337989-68-0)

Guidance literature:

Multi-step reaction with 2 steps

1: carbon tetrabromide; triphenylphosphine / diethyl ether / 16 h / 20 °C / Inert atmosphere

2: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 20 h / 20 °C / Reflux; Inert atmosphere

With carbon tetrabromide; potassium carbonate; triphenylphosphine; sodium iodide; In diethyl ether; N,N-dimethyl-formamide; 1: Appel reaction;

DOI:10.1016/j.bmcl.2011.08.029

upstream raw materials:

1-bromo-4-(3-methoxyphenyl)butane

3-methoxy-1-iodobenzene

4-(3-methoxyphenyl)butan-1-ol

4-(3-methoxyphenyl)-but-3-yn-1-ol