Benzene, 1-(4-bromobutyl)-3-methoxy-

Base Information

• Chemical Name: Benzene, 1-(4-bromobutyl)-3-methoxy-
• CAS No.: 23464-42-8
• Molecular Formula: C11H15BrO
• Molecular Weight: 243.143
• Mol file: 23464-42-8.mol

Synonyms:4-(m-Methoxy-phenyl)-butylbromid;1-(4-BROMOBUTYL)-3-METHOXYBENZENE;

Chemical Property of Benzene, 1-(4-bromobutyl)-3-methoxy-

Chemical Property:

• PSA: 9.23000
• LogP: 3.41280

Purity/Quality:

95%-98% ^*data from raw suppliers

1-(4-Bromobutyl)-3-methoxybenzene 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzene, 1-(4-bromobutyl)-3-methoxy-

There total 5 articles about Benzene, 1-(4-bromobutyl)-3-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-(3-methoxyphenyl)butan-1-ol (104174-43-8) → 1-bromo-4-(3-methoxyphenyl)butane (23464-42-8)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In diethyl ether; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.bmcl.2011.08.029

Reference yield: 64.0%

1,4-dibromo-butane (110-52-1) + 3-methoxyphenyl bromide (2398-37-0) → 1-bromo-4-(3-methoxyphenyl)butane (23464-42-8)

Guidance literature:

3-methoxyphenyl bromide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1.33333h; Inert atmosphere; Cooling with acetone-dry ice;

1,4-dibromo-butane; In tetrahydrofuran; hexane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/ejoc.201600460

Reference yield:

4-(3-methoxyphenyl)-but-3-yn-1-ol (92587-68-3) → 1-bromo-4-(3-methoxyphenyl)butane (23464-42-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / H₂ / 10 percent Pd/C / ethanol / 12 h / 20 °C / atmospheric pressure

2: 94 percent / CBr₄; Ph₃P / CH₂Cl₂ / 13 h / 0 - 20 °C

With carbon tetrabromide; hydrogen; triphenylphosphine; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1021/ja0300463

upstream raw materials:

4-(3-methoxyphenyl)butan-1-ol

3-methoxy-1-iodobenzene

4-(3-methoxyphenyl)-but-3-yn-1-ol

1,4-dibromo-butane

Downstream raw materials:

(2-{2-[4-(3-Methoxy-phenyl)-butyl]-1,1,3,3-tetraoxo-2,3-dihydro-1H-1λ⁶,3λ⁶-benzo[1,3]dithiol-2-yloxy}-ethyl)-trimethyl-silane

[4-(3-methoxyphenyl)butyl]methylcarbamic acid tert-butyl ester

[4-(3-methoxyphenyl)butyl]methylamine

1-(2-benzofuranylmethyl)-4-[4-(3-methoxyphenyl)butyl]piperazine