(1S,2S,5R)-(9H-fluoren-9-yl)methyl 2-((1R,2S,3S)-1,2-bis(benzyloxy)-4-(tertbutyldimethylsilyloxy)-3-(methylsulfonyloxy)butyl)-6-oxa-3-azabicyclo[3.1.0]hexane-3-carboxylate

Base Information

Chemical Name:(1S,2S,5R)-(9H-fluoren-9-yl)methyl 2-((1R,2S,3S)-1,2-bis(benzyloxy)-4-(tertbutyldimethylsilyloxy)-3-(methylsulfonyloxy)butyl)-6-oxa-3-azabicyclo[3.1.0]hexane-3-carboxylate
CAS No.:1204748-27-5
Molecular Formula:C₄₄H₅₃NO₉SSi
Molecular Weight:800.058
Hs Code.:

(1S,2S,5R)-(9H-fluoren-9-yl)methyl 2-((1R,2S,3S)-1,2-bis(benzyloxy)-4-(tertbutyldimethylsilyloxy)-3-(methylsulfonyloxy)butyl)-6-oxa-3-azabicyclo[3.1.0]hexane-3-carboxylate

Synonyms:(1S,2S,5R)-(9H-fluoren-9-yl)methyl 2-((1R,2S,3S)-1,2-bis(benzyloxy)-4-(tertbutyldimethylsilyloxy)-3-(methylsulfonyloxy)butyl)-6-oxa-3-azabicyclo[3.1.0]hexane-3-carboxylate

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Chemical Property of (1S,2S,5R)-(9H-fluoren-9-yl)methyl 2-((1R,2S,3S)-1,2-bis(benzyloxy)-4-(tertbutyldimethylsilyloxy)-3-(methylsulfonyloxy)butyl)-6-oxa-3-azabicyclo[3.1.0]hexane-3-carboxylate

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Technology Process of (1S,2S,5R)-(9H-fluoren-9-yl)methyl 2-((1R,2S,3S)-1,2-bis(benzyloxy)-4-(tertbutyldimethylsilyloxy)-3-(methylsulfonyloxy)butyl)-6-oxa-3-azabicyclo[3.1.0]hexane-3-carboxylate

There total 1 articles about (1S,2S,5R)-(9H-fluoren-9-yl)methyl 2-((1R,2S,3S)-1,2-bis(benzyloxy)-4-(tertbutyldimethylsilyloxy)-3-(methylsulfonyloxy)butyl)-6-oxa-3-azabicyclo[3.1.0]hexane-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1204748-26-4
(1S,2S,5R)-(9H-fluoren-9-yl)methyl 2-((1R,2R,3S)-1,2-bis(benzyloxy)-4-(tertbutyldimethylsilyloxy)-3-hydroxybutyl)-6-oxa-3-azabicyclo[3.1.0]hexane-3-carboxylate

: 124-63-0
methanesulfonyl chloride

: 1204748-27-5
(1S,2S,5R)-(9H-fluoren-9-yl)methyl 2-((1R,2S,3S)-1,2-bis(benzyloxy)-4-(tertbutyldimethylsilyloxy)-3-(methylsulfonyloxy)butyl)-6-oxa-3-azabicyclo[3.1.0]hexane-3-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jo902355p

Reference yield: 2.0%

: 1204748-27-5
(1S,2S,5R)-(9H-fluoren-9-yl)methyl 2-((1R,2S,3S)-1,2-bis(benzyloxy)-4-(tertbutyldimethylsilyloxy)-3-(methylsulfonyloxy)butyl)-6-oxa-3-azabicyclo[3.1.0]hexane-3-carboxylate

: 1204748-30-0
(1R,5R,6R,7R,7aR)-6,7-bis(benzyloxy)-5-(hydroxymethyl)hexahydro-1H-pyrrolizin-1-ol

: 1204748-31-1
C₂₂H₂₇NO₄

: 1204748-33-3
C₂₈H₄₁NO₄Si

: 1204748-43-5
(1R,6S,7S,8R,8aR)-7,8-bis(benzyloxy)-6-(tert-butyldimethylsilyloxy)octahydroindolizin-1-ol

: 1204748-32-2
(1R,5R,6R,7R,7aR)-6,7-bis(benzyloxy)-5-((tert-butyldimethylsilyloxy)methyl)hexahydro-1H-pyrrolizin-1-ol

Guidance literature:: (1S,2S,5R)-(9H-fluoren-9-yl)methyl 2-((1R,2S,3S)-1,2-bis(benzyloxy)-4-(tertbutyldimethylsilyloxy)-3-(methylsulfonyloxy)butyl)-6-oxa-3-azabicyclo[3.1.0]hexane-3-carboxylate; With piperidine; In acetonitrile; at 20 ℃; for 15h;

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 8h;
DOI:10.1021/jo902355p