(3-[4-(tert-Butoxycarbonyl)piperazin-1-yl]phenyl)boronic acid

Base Information

• Chemical Name: (3-[4-(tert-Butoxycarbonyl)piperazin-1-yl]phenyl)boronic acid
• CAS No.: 937048-39-0
• Molecular Formula: C₁₅H₂₃BN₂O₄
• Molecular Weight: 306.17
• Hs Code.: 2933998090
• Mol file: 937048-39-0.mol

Synonyms:3‐({4‐[(tert-butoxy)carbonyl]piperazin‐1‐yl}phenyl)boronic acid

Chemical Property of (3-[4-(tert-Butoxycarbonyl)piperazin-1-yl]phenyl)boronic acid

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

(3-(4-(tert-Butoxycarbonyl)piperazin-1-yl)phenyl)boronic acid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3-[4-(tert-Butoxycarbonyl)piperazin-1-yl]phenyl)boronic acid

There total 2 articles about (3-[4-(tert-Butoxycarbonyl)piperazin-1-yl]phenyl)boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

Triisopropyl borate (5419-55-6) + 1,1-dimethylethyl 4-(3-bromophenyl)piperazine-1-carboxylate (327030-39-7) → 3‐({4‐[(tert-butoxy)carbonyl]piperazin‐1‐yl}phenyl)boronic acid (937048-39-0)

Guidance literature:

1,1-dimethylethyl 4-(3-bromophenyl)piperazine-1-carboxylate; With n-butyllithium; In tetrahydrofuran; at -70 ℃; for 0.5h; Inert atmosphere;

Triisopropyl borate; In tetrahydrofuran; at -70 - 0 ℃; Inert atmosphere;

With phosphoric acid; ammonium chloride; In tetrahydrofuran; water; for 0.5h;

Reference yield:

1,3-dibromobenzene (108-36-1) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → 3‐({4‐[(tert-butoxy)carbonyl]piperazin‐1‐yl}phenyl)boronic acid (937048-39-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / 1,4-dioxane / 16 h / 90 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / 0.75 h / -78 °C

2.2: -78 °C

With n-butyllithium; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; 1,4-dioxane;

Reference yield: 84.0%

4-bromo-1H-pyrazole (2075-45-8) + 3‐({4‐[(tert-butoxy)carbonyl]piperazin‐1‐yl}phenyl)boronic acid (937048-39-0) → tert-butyl 4-(3-(4-bromo-1H-pyrazol-1-yl)phenyl)piperazine-1-carboxylate

Guidance literature:

With pyridine; copper diacetate; In dichloromethane; at 20 ℃; for 16h;

upstream raw materials:

Triisopropyl borate

1,1-dimethylethyl 4-(3-bromophenyl)piperazine-1-carboxylate

1,3-dibromobenzene

1-t-Butoxycarbonylpiperazine

Downstream raw materials:

4-[3-(4-amino-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester

tert-butyl 4-(3-(2,6-dichloroquinazolin-4-yl)phenyl)piperazine-1-carboxylate