Technology Process of (S)-iso-propyl α-hydroxy-α-(3-methylphenyl)acetate
There total 6 articles about (S)-iso-propyl α-hydroxy-α-(3-methylphenyl)acetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
3,3’-di(9-phenylanthryl)BINOL phosphoric acid; dibutylmagnesium; benzo[1,3,2]dioxaborole;
In
toluene; 1,3,5-trimethyl-benzene;
at 20 ℃;
for 24h;
enantioselective reaction;
Inert atmosphere;
Schlenk technique;
DOI:10.1039/c4cc00427b
- Guidance literature:
-
m-tolylboronic acid; isopropyl glyoxalate;
With
chlorobis(cyclooctene)rhodium(I) dimer; C19H23NOS;
In
1,4-dioxane;
at 20 ℃;
for 0.5h;
Inert atmosphere;
With
potassium hydroxide;
In
1,4-dioxane; water;
at 40 ℃;
for 5h;
Overall yield = 90 percent; enantioselective reaction;
Inert atmosphere;
DOI:10.1055/s-0037-1610722
- Guidance literature:
-
Multi-step reaction with 3 steps
1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 20 °C / Inert atmosphere
2: triethylamine / dichloromethane / 20 °C / Inert atmosphere
3: 3,3’-di(9-phenylanthryl)BINOL phosphoric acid; benzo[1,3,2]dioxaborole; dibutylmagnesium / 1,3,5-trimethyl-benzene; toluene / 24 h / 20 °C / Inert atmosphere; Schlenk technique
With
oxalyl dichloride; 3,3’-di(9-phenylanthryl)BINOL phosphoric acid; dibutylmagnesium; triethylamine; N,N-dimethyl-formamide; benzo[1,3,2]dioxaborole;
In
dichloromethane; toluene; 1,3,5-trimethyl-benzene;
DOI:10.1039/c4cc00427b