3-methylphenyloxoacetic acid

Base Information

• Chemical Name: 3-methylphenyloxoacetic acid
• CAS No.: 61560-94-9
• Molecular Formula: C₉H₈O₃
• Molecular Weight: 164.161
• Mol file: 61560-94-9.mol

Synonyms:3-methylphenyloxoacetic acid

Chemical Property of 3-methylphenyloxoacetic acid

Chemical Property:

• Melting Point: 112 °C
• Boiling Point: 150 °C(Press: 15 Torr)
• Density: 1.244±0.06 g/cm3(Predicted)

Purity/Quality:

(3-METHYLPHENYL)GLYOXYLICACID ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-methylphenyloxoacetic acid

There total 13 articles about 3-methylphenyloxoacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-Methylacetophenone (585-74-0) → 3-methylphenyloxoacetic acid (61560-94-9)

Guidance literature:

With selenium(IV) oxide; In pyridine; for 3.5h; Heating / reflux;

Reference yield: 97.2%

m-methyl-2-(hydroxyimino)-2-phenylacetonitrile → 3-methylphenyloxoacetic acid (61560-94-9)

Guidance literature:

With sulfuric acid; at 100 - 120 ℃; for 6h;

Reference yield: 77.0%

3-methylstyrene (100-80-1) → 3-methylphenyloxoacetic acid (61560-94-9)

Guidance literature:

With tert.-butylhydroperoxide; water; tetra-(n-butyl)ammonium iodide; In acetonitrile; at 90 ℃; for 12h; Inert atmosphere; Glovebox; Schlenk technique; Green chemistry;

DOI:10.1021/acs.orglett.1c02021

upstream raw materials:

ethyl 2-oxo-2-(m-tolyl)acetate

3-Methylacetophenone

3-methylmandelic acid

carbon monoxide

Downstream raw materials:

m-tolyl aldehyde

m-Toluic acid

5-Hydroxy-6-m-tolyl-pyrazine-2,3-dicarbonitrile

N-(2-chlorophenyl)-N-methyl-2-oxo-2-m-tolylacetamide

Refernces

• 1、 Long, Lipeng,Wang, Jieyan,Gu, Liuqing,Yang, Shiguang,Qiao, Liang,Luo, Guotian,Chen, Zhengwang. "Hypervalent Iodine(III)-Promoted Radical Oxidative C-H Annulation of Arylamines with α-Keto Acids". supporting information. p. 12084 - 12092. Retrieved 2021/08/24.
• 2、 Chen, Bin,Cheng, Yuan-Yuan,Hou, Hong-Yu,Lei, Tao,Tung, Chen-Ho,Wu, Li-Zhu,Yu, Ji-Xin. "Direct 1,2-Dicarbonylation of Alkenes towards 1,4-Diketones via Photocatalysis". supporting information. p. 26822 - 26828. Retrieved 2021/11/17.