5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester

Base Information

Chemical Name:5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester
CAS No.:899808-36-7
Molecular Formula:C₂₈H₂₈F₃NO₅S
Molecular Weight:547.595
Hs Code.:

5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidine-1,3-dicarboxylic acid 1-<i>tert</i>-butyl ester

Synonyms:5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester

There total 11 articles about 5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 899808-35-6
5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester

: 899808-36-7
5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester

Guidance literature:: With sodium hydroxide; In ethanol;
DOI:10.1016/j.bmcl.2006.03.090

Reference yield:

: 899808-27-6
5-bromomethyl-3-phenyl-2-trifluoromethyl-thiophene

: 899808-36-7
5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 96 percent / K₂CO₃ / acetonitrile / 60 °C

2.1: 90 percent / DMAP / CH₂Cl₂ / 20 °C

3.1: LiN(TMS)2 / tetrahydrofuran / -78 °C

3.2: 83 percent / tetrahydrofuran / -78 °C

4.1: 81 percent / HCl / ethanol / 20 °C

5.1: Meerwein's salt / CH₂Cl₂ / 20 °C

5.2: NaCNBH₃ / methanol / 20 °C / pH 3 - 4

6.1: DMAP / CH₂Cl₂ / 20 °C

7.1: 100 percent / NaOH / ethanol

With hydrogenchloride; dmap; sodium hydroxide; Meerwein's salt; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2006.03.090

Reference yield:

: 899808-28-7
5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidin-2-one

: 899808-36-7
5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 90 percent / DMAP / CH₂Cl₂ / 20 °C

2.1: LiN(TMS)2 / tetrahydrofuran / -78 °C

2.2: 83 percent / tetrahydrofuran / -78 °C

3.1: 81 percent / HCl / ethanol / 20 °C

4.1: Meerwein's salt / CH₂Cl₂ / 20 °C

4.2: NaCNBH₃ / methanol / 20 °C / pH 3 - 4

5.1: DMAP / CH₂Cl₂ / 20 °C

6.1: 100 percent / NaOH / ethanol

With hydrogenchloride; dmap; sodium hydroxide; Meerwein's salt; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2006.03.090