5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidin-2-one

Base Information

Chemical Name:5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidin-2-one
CAS No.:899808-28-7
Molecular Formula:C₂₂H₁₈F₃NO₂S
Molecular Weight:417.452
Hs Code.:

Synonyms:5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidin-2-one

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Chemical Property of 5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidin-2-one

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Technology Process of 5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidin-2-one

There total 4 articles about 5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 899808-27-6
5-bromomethyl-3-phenyl-2-trifluoromethyl-thiophene

: 207989-87-5
5-(4-hydroxy-phenyl)-pyrrolidin-2-one

: 899808-28-7
5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidin-2-one

Guidance literature:: With potassium carbonate; In acetonitrile; at 60 ℃;
DOI:10.1016/j.bmcl.2006.03.090

Reference yield:

: 128100-35-6
5-(4-methoxyphenyl)pyrrolidin-2-one

: 899808-28-7
5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / BBr₃ / CH₂Cl₂ / -78 - 0 °C

2: 96 percent / K₂CO₃ / acetonitrile / 60 °C

With boron tribromide; potassium carbonate; In dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2006.03.090

Reference yield:

: 100-66-3
methoxybenzene

: 899808-28-7
5-[4-(4-phenyl-5-trifluoromethyl-thiophen-2-ylmethoxy)-phenyl]-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 54 percent / P₂O₅; CH₃SO₃H / 100 °C

2: 80 percent / BBr₃ / CH₂Cl₂ / -78 - 0 °C

3: 96 percent / K₂CO₃ / acetonitrile / 60 °C

With methanesulfonic acid; phosphorus pentoxide; boron tribromide; potassium carbonate; In dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2006.03.090