(S)-3-hydroxy-2-methyl-1-oxo-1-((4-((2-oxo-1,2-dihydropyrimidin-4-yl)carbamoyl)phenyl)amino)propan-2-aminium chloride

Base Information

Chemical Name:(S)-3-hydroxy-2-methyl-1-oxo-1-((4-((2-oxo-1,2-dihydropyrimidin-4-yl)carbamoyl)phenyl)amino)propan-2-aminium chloride
CAS No.:1333077-71-6
Molecular Formula:C₁₅H₁₇N₅O₄*ClH
Molecular Weight:367.792
Hs Code.:

Synonyms:(S)-3-hydroxy-2-methyl-1-oxo-1-((4-((2-oxo-1,2-dihydropyrimidin-4-yl)carbamoyl)phenyl)amino)propan-2-aminium chloride

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Chemical Property of (S)-3-hydroxy-2-methyl-1-oxo-1-((4-((2-oxo-1,2-dihydropyrimidin-4-yl)carbamoyl)phenyl)amino)propan-2-aminium chloride

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Technology Process of (S)-3-hydroxy-2-methyl-1-oxo-1-((4-((2-oxo-1,2-dihydropyrimidin-4-yl)carbamoyl)phenyl)amino)propan-2-aminium chloride

There total 2 articles about (S)-3-hydroxy-2-methyl-1-oxo-1-((4-((2-oxo-1,2-dihydropyrimidin-4-yl)carbamoyl)phenyl)amino)propan-2-aminium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1333077-66-9
(2R,4S)-tert-butyl 4-((4-((2-(allyloxy)pyrimidin-4-yl)carbamoyl)phenyl)carbamoyl)-2-(tert-butyl)-4-methyloxazolidine-3-carboxylate

: 1333077-71-6
(S)-3-hydroxy-2-methyl-1-oxo-1-((4-((2-oxo-1,2-dihydropyrimidin-4-yl)carbamoyl)phenyl)amino)propan-2-aminium chloride

Guidance literature:: With hydrogenchloride; In water; at 70 ℃; for 0.25h; Inert atmosphere; Microwave irradiation;
DOI:10.1021/ol2018196

Reference yield:

: 1333077-65-8
N-(2-(allyloxy)pyrimidin-4-yl)-4-iodobenzamide

: 1333077-71-6
(S)-3-hydroxy-2-methyl-1-oxo-1-((4-((2-oxo-1,2-dihydropyrimidin-4-yl)carbamoyl)phenyl)amino)propan-2-aminium chloride

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 60 h / 100 °C / Inert atmosphere

2: hydrogenchloride / water / 0.25 h / 70 °C / Inert atmosphere; Microwave irradiation

With hydrogenchloride; copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine; In 1,4-dioxane; water;
DOI:10.1021/ol2018196