O-(tert-butyldiphenylsilyl)-2-methylene-4-(2,2-dimethyl-4H-1,3-dioxin-4-one-6-yl)-5-(4-bromo-1-methylindol-3-yl)-5-methyl-hexan-1-ol

Base Information

Chemical Name:O-(tert-butyldiphenylsilyl)-2-methylene-4-(2,2-dimethyl-4H-1,3-dioxin-4-one-6-yl)-5-(4-bromo-1-methylindol-3-yl)-5-methyl-hexan-1-ol
CAS No.:1228023-15-1
Molecular Formula:C₃₉H₄₆BrNO₄Si
Molecular Weight:700.788
Hs Code.:

Synonyms:O-(tert-butyldiphenylsilyl)-2-methylene-4-(2,2-dimethyl-4H-1,3-dioxin-4-one-6-yl)-5-(4-bromo-1-methylindol-3-yl)-5-methyl-hexan-1-ol

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Chemical Property of O-(tert-butyldiphenylsilyl)-2-methylene-4-(2,2-dimethyl-4H-1,3-dioxin-4-one-6-yl)-5-(4-bromo-1-methylindol-3-yl)-5-methyl-hexan-1-ol

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Technology Process of O-(tert-butyldiphenylsilyl)-2-methylene-4-(2,2-dimethyl-4H-1,3-dioxin-4-one-6-yl)-5-(4-bromo-1-methylindol-3-yl)-5-methyl-hexan-1-ol

There total 8 articles about O-(tert-butyldiphenylsilyl)-2-methylene-4-(2,2-dimethyl-4H-1,3-dioxin-4-one-6-yl)-5-(4-bromo-1-methylindol-3-yl)-5-methyl-hexan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1441119-24-9
C₁₂H₁₄BrNO

: 1228023-12-8
C₃₀H₄₂O₄Si₂

: 1228023-15-1
O-(tert-butyldiphenylsilyl)-2-methylene-4-(2,2-dimethyl-4H-1,3-dioxin-4-one-6-yl)-5-(4-bromo-1-methylindol-3-yl)-5-methyl-hexan-1-ol

Guidance literature:: C₁₂H₁₄BrNO; With trimethylsilyl trifluoromethanesulfonate; In toluene; at -78 ℃; for 0.0333333h;

C₃₀H₄₂O₄Si₂; In toluene; at -78 - 20 ℃;
DOI:10.1021/ol1006373

Reference yield:

: 1228023-14-0
6-(4-tert-butyldiphenylsilyloxy-3-methylidenebutyl)-2,2-dimethyl-4H-1,3-dioxin-4-one

: 1228023-15-1
O-(tert-butyldiphenylsilyl)-2-methylene-4-(2,2-dimethyl-4H-1,3-dioxin-4-one-6-yl)-5-(4-bromo-1-methylindol-3-yl)-5-methyl-hexan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere

1.2: 0.83 h / Inert atmosphere

2.1: trimethylsilyl trifluoromethanesulfonate / toluene / 0.03 h / -78 °C

2.2: 19.5 h / -78 - 20 °C

With trimethylsilyl trifluoromethanesulfonate; sodium hexamethyldisilazane; In tetrahydrofuran; toluene;
DOI:10.1016/j.tet.2013.03.010

Reference yield:

: 913253-34-6
{[2-(bromomethyl)prop-2-en-1-yl]oxy}(tert-butyl)diphenylsilane

: 1228023-15-1
O-(tert-butyldiphenylsilyl)-2-methylene-4-(2,2-dimethyl-4H-1,3-dioxin-4-one-6-yl)-5-(4-bromo-1-methylindol-3-yl)-5-methyl-hexan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran / 0.83 h / 0 °C / Inert atmosphere

1.2: 3.92 h / -78 - 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / acetone / 22 h

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere

3.2: 0.83 h / Inert atmosphere

4.1: trimethylsilyl trifluoromethanesulfonate / toluene / 0.03 h / -78 °C

4.2: 19.5 h / -78 - 20 °C

With n-butyllithium; trimethylsilyl trifluoromethanesulfonate; sodium hexamethyldisilazane; diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; hexane; acetone; toluene;
DOI:10.1016/j.tet.2013.03.010