6-[(1-methylethyl)sulfonyl]-3-[(3-methyl-4-oxo-1-piperidinyl)methyl]-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide

Base Information

Chemical Name:6-[(1-methylethyl)sulfonyl]-3-[(3-methyl-4-oxo-1-piperidinyl)methyl]-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide
CAS No.:1335116-97-6
Molecular Formula:C₃₅H₃₃F₆N₃O₄S
Molecular Weight:705.721
Hs Code.:

6-[(1-methylethyl)sulfonyl]-3-[(3-methyl-4-oxo-1-piperidinyl)methyl]-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide

Synonyms:6-[(1-methylethyl)sulfonyl]-3-[(3-methyl-4-oxo-1-piperidinyl)methyl]-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide

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Chemical Property of 6-[(1-methylethyl)sulfonyl]-3-[(3-methyl-4-oxo-1-piperidinyl)methyl]-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide

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Technology Process of 6-[(1-methylethyl)sulfonyl]-3-[(3-methyl-4-oxo-1-piperidinyl)methyl]-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide

There total 9 articles about 6-[(1-methylethyl)sulfonyl]-3-[(3-methyl-4-oxo-1-piperidinyl)methyl]-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1335116-96-5
6-[(1-methylethyl)sulfonyl]-3-[(3-methyl-4-oxo-1-piperidinyl)methyl]-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

: 22038-85-3
(R)-(-)-2,2,2-Trifluoro-1-phenylethylamine

: 1335116-97-6
6-[(1-methylethyl)sulfonyl]-3-[(3-methyl-4-oxo-1-piperidinyl)methyl]-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 1533-03-5
3-(trifluoromethyl)propiophenone

: 1335116-97-6
6-[(1-methylethyl)sulfonyl]-3-[(3-methyl-4-oxo-1-piperidinyl)methyl]-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium hydroxide / ethanol; water / 1 h / Reflux

1.2: pH ~ 3

2.1: potassium hydroxide / water

2.2: 100 °C

2.3: 1 h

3.1: Oxone / water; tetrahydrofuran / 20 °C

4.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 100 °C

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 22 h / 20 °C

6.1: sodium hydroxide; methanol / tetrahydrofuran / 20 h / 50 °C

7.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane / 0 - 20 °C

With methanol; Oxone; N-Bromosuccinimide; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; potassium hydroxide; sodium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: 1335116-97-6
6-[(1-methylethyl)sulfonyl]-3-[(3-methyl-4-oxo-1-piperidinyl)methyl]-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium hydroxide / ethanol; water / 1 h / Reflux

1.2: pH ~ 3

2.1: potassium hydroxide / water

2.2: 100 °C

2.3: 1 h

3.1: Oxone / water; tetrahydrofuran / 20 °C

4.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 100 °C

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 22 h / 20 °C

6.1: sodium hydroxide; methanol / tetrahydrofuran / 20 h / 50 °C

7.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane / 0 - 20 °C

With methanol; Oxone; N-Bromosuccinimide; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; potassium hydroxide; sodium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; water; acetonitrile;