6-[(1-methylethyl)sulfonyl]-3-{[3-methyl-4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide

Base Information

Chemical Name:6-[(1-methylethyl)sulfonyl]-3-{[3-methyl-4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide
CAS No.:1335115-41-7
Molecular Formula:C₃₉H₄₂F₆N₄O₄S
Molecular Weight:776.843
Hs Code.:

6-[(1-methylethyl)sulfonyl]-3-{[3-methyl-4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide

Synonyms:6-[(1-methylethyl)sulfonyl]-3-{[3-methyl-4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide

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Chemical Property of 6-[(1-methylethyl)sulfonyl]-3-{[3-methyl-4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide

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Technology Process of 6-[(1-methylethyl)sulfonyl]-3-{[3-methyl-4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide

There total 10 articles about 6-[(1-methylethyl)sulfonyl]-3-{[3-methyl-4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 110-91-8,99108-56-2
morpholine

: 1335116-97-6
6-[(1-methylethyl)sulfonyl]-3-[(3-methyl-4-oxo-1-piperidinyl)methyl]-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide

: 1335115-41-7
6-[(1-methylethyl)sulfonyl]-3-{[3-methyl-4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃; for 72h;

Reference yield:

: 1533-03-5
3-(trifluoromethyl)propiophenone

: 1335115-41-7
6-[(1-methylethyl)sulfonyl]-3-{[3-methyl-4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium hydroxide / ethanol; water / 1 h / Reflux

1.2: pH ~ 3

2.1: potassium hydroxide / water

2.2: 100 °C

2.3: 1 h

3.1: Oxone / water; tetrahydrofuran / 20 °C

4.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 100 °C

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 22 h / 20 °C

6.1: sodium hydroxide; methanol / tetrahydrofuran / 20 h / 50 °C

7.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane / 0 - 20 °C

8.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 72 h / 20 °C

With methanol; Oxone; N-Bromosuccinimide; sodium tris(acetoxy)borohydride; acetic acid; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; potassium hydroxide; sodium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: 1335115-41-7
6-[(1-methylethyl)sulfonyl]-3-{[3-methyl-4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]N-[(1R)-2,2,2-trifluoro-1-phenylethyl]-4-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium hydroxide / ethanol; water / 1 h / Reflux

1.2: pH ~ 3

2.1: potassium hydroxide / water

2.2: 100 °C

2.3: 1 h

3.1: Oxone / water; tetrahydrofuran / 20 °C

4.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 100 °C

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 22 h / 20 °C

6.1: sodium hydroxide; methanol / tetrahydrofuran / 20 h / 50 °C

7.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane / 0 - 20 °C

8.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 72 h / 20 °C

With methanol; Oxone; N-Bromosuccinimide; sodium tris(acetoxy)borohydride; acetic acid; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; potassium hydroxide; sodium hydroxide; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; water; acetonitrile;