n-propyl 4-((1Z)-2-{[(benzyloxy)carbonyl]amino}-3-methoxy-3-oxo-1-propenyl)-6-methoxy-2-pyridinecarboxylate

Base Information

Chemical Name:n-propyl 4-((1Z)-2-{[(benzyloxy)carbonyl]amino}-3-methoxy-3-oxo-1-propenyl)-6-methoxy-2-pyridinecarboxylate
CAS No.:308357-95-1
Molecular Formula:C₂₂H₂₄N₂O₇
Molecular Weight:428.442
Hs Code.:

Synonyms:n-propyl 4-((1Z)-2-{[(benzyloxy)carbonyl]amino}-3-methoxy-3-oxo-1-propenyl)-6-methoxy-2-pyridinecarboxylate

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Chemical Property of n-propyl 4-((1Z)-2-{[(benzyloxy)carbonyl]amino}-3-methoxy-3-oxo-1-propenyl)-6-methoxy-2-pyridinecarboxylate

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Technology Process of n-propyl 4-((1Z)-2-{[(benzyloxy)carbonyl]amino}-3-methoxy-3-oxo-1-propenyl)-6-methoxy-2-pyridinecarboxylate

There total 5 articles about n-propyl 4-((1Z)-2-{[(benzyloxy)carbonyl]amino}-3-methoxy-3-oxo-1-propenyl)-6-methoxy-2-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 100945-15-1,88568-95-0
N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester

: 308357-97-3
n-propyl 4-formyl-6-methoxy-2-pyridinecarboxylate

: n-propyl 4-((1E)-2-{[(benzyloxy)carbonyl]amino}-3-methoxy-3-oxo-1-propenyl)-6-methoxy-2-pyridinecarboxylate

: 308357-95-1
n-propyl 4-((1Z)-2-{[(benzyloxy)carbonyl]amino}-3-methoxy-3-oxo-1-propenyl)-6-methoxy-2-pyridinecarboxylate

Guidance literature:: With N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; at 0 - 20 ℃; for 6h;
DOI:10.1021/ol006363l

Reference yield:

: 5398-44-7
2,6-dichloropyridine-4-carboxylic acid

: 308357-95-1
n-propyl 4-((1Z)-2-{[(benzyloxy)carbonyl]amino}-3-methoxy-3-oxo-1-propenyl)-6-methoxy-2-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / NaOMe / 48 h / Heating

2: BH₃*THF / tetrahydrofuran / 0 - 20 °C

3: 45 percent / Pd(OAc)2; 1,3-bis(diphenylphosphino)propane; K₂CO₃ / dimethylformamide / 90 °C / 775.72 Torr

4: 30 percent / MnO₂ / CHCl₃ / 48 h / 20 °C

5: 76 percent / N,N,N',N'-tetramethylguanidine / tetrahydrofuran / 0 - 20 °C

With manganese(IV) oxide; palladium diacetate; borane-THF; 1,3-bis-(diphenylphosphino)propane; sodium methylate; potassium carbonate; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(02)00670-1

Reference yield:

: 193001-91-1
2-chloro-4-hydroxymethyl-6-methoxypyridine

: 308357-95-1
n-propyl 4-((1Z)-2-{[(benzyloxy)carbonyl]amino}-3-methoxy-3-oxo-1-propenyl)-6-methoxy-2-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 45 percent / Pd(OAc)2; 1,3-bis(diphenylphosphino)propane; K₂CO₃ / dimethylformamide / 90 °C / 775.72 Torr

2: 30 percent / MnO₂ / CHCl₃ / 48 h / 20 °C

3: 76 percent / N,N,N',N'-tetramethylguanidine / tetrahydrofuran / 0 - 20 °C

With manganese(IV) oxide; palladium diacetate; 1,3-bis-(diphenylphosphino)propane; potassium carbonate; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(02)00670-1