(2-Chloro-6-methoxypyridin-4-yl)methanol

Base Information

• Chemical Name: (2-Chloro-6-methoxypyridin-4-yl)methanol
• CAS No.: 193001-91-1
• Molecular Formula: C7H8 Cl N O2
• Molecular Weight: 173.599
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID50466455
• Nikkaji Number: J1.478.178A
• Wikidata: Q82293024
• Mol file: 193001-91-1.mol

Synonyms:(2-chloro-6-methoxypyridin-4-yl)methanol;193001-91-1;(2-CHLORO-6-METHOXY-PYRIDIN-4-YL)-METHANOL;4-Pyridinemethanol,2-chloro-6-methoxy-;SCHEMBL2541070;DTXSID50466455;LGAAPDVGNCACDI-UHFFFAOYSA-N;MFCD09029989;2-chloro-6-methoxy-4-pyridinemethanol;AKOS006288116;AB49302;EF-0706;CS-0150457;[2-chloro-6-(methyloxy)-4-pyridinyl]methanol;EN300-7424264;2-CHLORO-4-HYDROXYMETHYL-6-METHOXYPYRIDINE;A880293

Chemical Property of (2-Chloro-6-methoxypyridin-4-yl)methanol

Chemical Property:

• PSA: 42.35000
• LogP: 1.23590
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 173.0243562
• Heavy Atom Count: 11
• Complexity: 123

Purity/Quality:

97% ^*data from raw suppliers

(2-Chloro-6-methoxypyridin-4-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=NC(=CC(=C1)CO)Cl

Technology Process of (2-Chloro-6-methoxypyridin-4-yl)methanol

There total 2 articles about (2-Chloro-6-methoxypyridin-4-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-chloro-6-methoxyisonicotinic acid methyl ester (42521-10-8) → 2-chloro-4-hydroxymethyl-6-methoxypyridine (193001-91-1)

Guidance literature:

With lithium borohydride; ethanol; In tetrahydrofuran; at 20 ℃; for 15h;

Reference yield:

2,6-dichloropyridine-4-carboxylic acid (5398-44-7) → 2-chloro-4-hydroxymethyl-6-methoxypyridine (193001-91-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / NaOMe / 48 h / Heating

2: BH₃*THF / tetrahydrofuran / 0 - 20 °C

With borane-THF; sodium methylate; In tetrahydrofuran;

DOI:10.1016/S0040-4020(02)00670-1

Reference yield: 74.0%

2-chloro-4-hydroxymethyl-6-methoxypyridine (193001-91-1) → 2-chloro-4-(chloromethyl)-6-methoxypyridine hydrochloride

Guidance literature:

With thionyl chloride; In toluene;

upstream raw materials:

2,6-dichloropyridine-4-carboxylic acid

2-chloro-6-methoxyisonicotinic acid methyl ester

Downstream raw materials:

4-(bromomethyl)-2-chloro-6-methoxypyridine

3-benzyl-10-(hydroxymethyl)-1,2,3,4,5,6-hexahydro-1,5-methanopyrido[1,2-a][1,5]diazocin-8-one

3-benzyl-10-[(methoxymethoxy)methyl]-1,2,3,4,5,6-hexahydro-1,5-methanopyrido[1,2-a][1,5]diazocin-8-one

1'-benzyl-5'-hydroxymethyl-6-methoxy-4-[(methoxymethoxy)methyl]-[2,3']bipyridinyl-1'-ium bromide