1-(5-amino-2-fluoro-4-(methylsulfonyl)phenyl)-7-(3, 5-dimethylisoxazol-4-yl)-2-methyl-1, 4-dihydro-4-oxoquinoline

Base Information

Chemical Name:1-(5-amino-2-fluoro-4-(methylsulfonyl)phenyl)-7-(3, 5-dimethylisoxazol-4-yl)-2-methyl-1, 4-dihydro-4-oxoquinoline
CAS No.:1315179-86-2
Molecular Formula:C₂₂H₂₀FN₃O₄S
Molecular Weight:441.483
Hs Code.:

Synonyms:1-(5-amino-2-fluoro-4-(methylsulfonyl)phenyl)-7-(3, 5-dimethylisoxazol-4-yl)-2-methyl-1, 4-dihydro-4-oxoquinoline

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Chemical Property of 1-(5-amino-2-fluoro-4-(methylsulfonyl)phenyl)-7-(3, 5-dimethylisoxazol-4-yl)-2-methyl-1, 4-dihydro-4-oxoquinoline

Chemical Property:

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Technology Process of 1-(5-amino-2-fluoro-4-(methylsulfonyl)phenyl)-7-(3, 5-dimethylisoxazol-4-yl)-2-methyl-1, 4-dihydro-4-oxoquinoline

There total 5 articles about 1-(5-amino-2-fluoro-4-(methylsulfonyl)phenyl)-7-(3, 5-dimethylisoxazol-4-yl)-2-methyl-1, 4-dihydro-4-oxoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1315180-56-3
C₂₄H₂₂FN₃O₅S

: 1315179-86-2
1-(5-amino-2-fluoro-4-(methylsulfonyl)phenyl)-7-(3, 5-dimethylisoxazol-4-yl)-2-methyl-1, 4-dihydro-4-oxoquinoline

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; for 0.666667h; Reflux;

Reference yield:

: 1315180-19-8
tert-butyl 5-amino-4-bromo-2-fluorophenylcarbamate

: 1315179-86-2
1-(5-amino-2-fluoro-4-(methylsulfonyl)phenyl)-7-(3, 5-dimethylisoxazol-4-yl)-2-methyl-1, 4-dihydro-4-oxoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / ethyl acetate / 3.25 h / 20 °C

1.2: 7.83 h / 20 °C

2.1: acetic acid / ethanol / 1.5 h / 70 - 80 °C

3.1: potassium carbonate / dimethyl sulfoxide / 4.5 h / 75 - 80 °C

4.1: sodium hydroxide; copper(l) iodide; rac-Pro-OH / dimethyl sulfoxide / 13.5 h / 110 - 120 °C

5.1: hydrogenchloride / 1,4-dioxane / 0.67 h / Reflux

With hydrogenchloride; copper(l) iodide; potassium carbonate; acetic acid; triethylamine; rac-Pro-OH; sodium hydroxide; In 1,4-dioxane; ethanol; dimethyl sulfoxide; ethyl acetate;

Reference yield:

: 1315179-85-1
1-(5-acetylamino-4-bromo-2-fluorophenyl)-7-(3, 5-dimethylisoxazol-4-yl)-2-methyl-1, 4-dihydro-4-oxoquinoline

: 1315179-86-2
1-(5-amino-2-fluoro-4-(methylsulfonyl)phenyl)-7-(3, 5-dimethylisoxazol-4-yl)-2-methyl-1, 4-dihydro-4-oxoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; copper(l) iodide; rac-Pro-OH / dimethyl sulfoxide / 13.5 h / 110 - 120 °C

2: hydrogenchloride / 1,4-dioxane / 0.67 h / Reflux

With hydrogenchloride; copper(l) iodide; rac-Pro-OH; sodium hydroxide; In 1,4-dioxane; dimethyl sulfoxide;