2-[3-(1,2,3,4-tetrahydro-isoquinolin-7-ylcarbamoyl)-phenyl]-pyrrolidine-1-carboxylic acid (3-cyano-phenyl)-amide trifluoroacetate

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Chemical Name:2-[3-(1,2,3,4-tetrahydro-isoquinolin-7-ylcarbamoyl)-phenyl]-pyrrolidine-1-carboxylic acid (3-cyano-phenyl)-amide trifluoroacetate
CAS No.:1354719-15-5
Molecular Formula:C₂HF₃O₂*C₂₈H₂₇N₅O₂
Molecular Weight:579.579
Hs Code.:

Synonyms:2-[3-(1,2,3,4-tetrahydro-isoquinolin-7-ylcarbamoyl)-phenyl]-pyrrolidine-1-carboxylic acid (3-cyano-phenyl)-amide trifluoroacetate

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Chemical Property of 2-[3-(1,2,3,4-tetrahydro-isoquinolin-7-ylcarbamoyl)-phenyl]-pyrrolidine-1-carboxylic acid (3-cyano-phenyl)-amide trifluoroacetate

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Technology Process of 2-[3-(1,2,3,4-tetrahydro-isoquinolin-7-ylcarbamoyl)-phenyl]-pyrrolidine-1-carboxylic acid (3-cyano-phenyl)-amide trifluoroacetate

There total 6 articles about 2-[3-(1,2,3,4-tetrahydro-isoquinolin-7-ylcarbamoyl)-phenyl]-pyrrolidine-1-carboxylic acid (3-cyano-phenyl)-amide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354721-19-9
7-{3-[1-(3-cyanophenylcarbamoyl)-pyrrolidin-2-yl]-benzoylamino}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester

: 76-05-1
trifluoroacetic acid

: 1354719-15-5
2-[3-(1,2,3,4-tetrahydro-isoquinolin-7-ylcarbamoyl)-phenyl]-pyrrolidine-1-carboxylic acid (3-cyano-phenyl)-amide trifluoroacetate

Guidance literature:: 7-{3-[1-(3-cyanophenylcarbamoyl)-pyrrolidin-2-yl]-benzoylamino}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester; With hydrogen; palladium 10% on activated carbon; In methanol; for 48h; under 760.051 Torr;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 787640-41-9
benzyl 7-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1354719-15-5
2-[3-(1,2,3,4-tetrahydro-isoquinolin-7-ylcarbamoyl)-phenyl]-pyrrolidine-1-carboxylic acid (3-cyano-phenyl)-amide trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h / 20 °C

1.2: 24 h / 65 °C

2.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 24 h / 20 °C

3.1: triethylamine / N,N-dimethyl-formamide / 72 h / 20 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / 48 h / 760.05 Torr

With hydrogenchloride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 99365-69-2
7-nitro-1,2,3,4-tetrahydroisoquinoline hydrochloride

: 1354719-15-5
2-[3-(1,2,3,4-tetrahydro-isoquinolin-7-ylcarbamoyl)-phenyl]-pyrrolidine-1-carboxylic acid (3-cyano-phenyl)-amide trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / ethyl acetate; water / 24 h / 0 - 20 °C

2.1: hydrogenchloride; tin(ll) chloride; acetic acid; tin(II) chloride dihdyrate / water / 48 h / 20 °C

2.2: 1.08 h / pH 5 - 10 / Cooling with ice

3.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h / 20 °C

3.2: 24 h / 65 °C

4.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 24 h / 20 °C

5.1: triethylamine / N,N-dimethyl-formamide / 72 h / 20 °C

6.1: hydrogen / palladium 10% on activated carbon / methanol / 48 h / 760.05 Torr

With hydrogenchloride; tin(II) chloride dihdyrate; hydrogen; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; tin(ll) chloride; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;