7-{3-[1-(3-cyanophenylcarbamoyl)-pyrrolidin-2-yl]-benzoylamino}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester

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Chemical Name:7-{3-[1-(3-cyanophenylcarbamoyl)-pyrrolidin-2-yl]-benzoylamino}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester
CAS No.:1354721-19-9
Molecular Formula:C₃₆H₃₃N₅O₄
Molecular Weight:599.689
Hs Code.:

Synonyms:7-{3-[1-(3-cyanophenylcarbamoyl)-pyrrolidin-2-yl]-benzoylamino}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester

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Chemical Property of 7-{3-[1-(3-cyanophenylcarbamoyl)-pyrrolidin-2-yl]-benzoylamino}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester

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Technology Process of 7-{3-[1-(3-cyanophenylcarbamoyl)-pyrrolidin-2-yl]-benzoylamino}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester

There total 6 articles about 7-{3-[1-(3-cyanophenylcarbamoyl)-pyrrolidin-2-yl]-benzoylamino}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354721-17-7
7-(3-pyrrolidin-2-ylbenzoylamino)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester hydrochloride

: 16413-26-6
3-cyanophenyl isocyanate

: 1354721-19-9
7-{3-[1-(3-cyanophenylcarbamoyl)-pyrrolidin-2-yl]-benzoylamino}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 72h;

Reference yield:

: 99365-69-2
7-nitro-1,2,3,4-tetrahydroisoquinoline hydrochloride

: 1354721-19-9
7-{3-[1-(3-cyanophenylcarbamoyl)-pyrrolidin-2-yl]-benzoylamino}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / ethyl acetate; water / 24 h / 0 - 20 °C

2.1: hydrogenchloride; tin(ll) chloride; acetic acid; tin(II) chloride dihdyrate / water / 48 h / 20 °C

2.2: 1.08 h / pH 5 - 10 / Cooling with ice

3.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h / 20 °C

3.2: 24 h / 65 °C

4.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 24 h / 20 °C

5.1: triethylamine / N,N-dimethyl-formamide / 72 h / 20 °C

With hydrogenchloride; tin(II) chloride dihdyrate; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; tin(ll) chloride; In 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1354721-19-9
7-{3-[1-(3-cyanophenylcarbamoyl)-pyrrolidin-2-yl]-benzoylamino}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / ethyl acetate; water / 24 h / 0 - 20 °C

2.1: hydrogenchloride; tin(ll) chloride; acetic acid; tin(II) chloride dihdyrate / water / 48 h / 20 °C

2.2: 1.08 h / pH 5 - 10 / Cooling with ice

3.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h / 20 °C

3.2: 24 h / 65 °C

4.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 24 h / 20 °C

5.1: triethylamine / N,N-dimethyl-formamide / 72 h / 20 °C

With hydrogenchloride; tin(II) chloride dihdyrate; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; tin(ll) chloride; In 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;