(R)-[1-(4-fluorophenyl)-3-(4-pentylphenyl)-prop-2-ynyl]-(4-methoxyphenyl)amine

Base Information

• Chemical Name: (R)-[1-(4-fluorophenyl)-3-(4-pentylphenyl)-prop-2-ynyl]-(4-methoxyphenyl)amine
• CAS No.: 1373775-51-9
• Molecular Formula: C₂₇H₂₈FNO
• Molecular Weight: 401.524

Synonyms:(R)-[1-(4-fluorophenyl)-3-(4-pentylphenyl)-prop-2-ynyl]-(4-methoxyphenyl)amine

Chemical Property of (R)-[1-(4-fluorophenyl)-3-(4-pentylphenyl)-prop-2-ynyl]-(4-methoxyphenyl)amine

Chemical Property:

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Technology Process of (R)-[1-(4-fluorophenyl)-3-(4-pentylphenyl)-prop-2-ynyl]-(4-methoxyphenyl)amine

There total 3 articles about (R)-[1-(4-fluorophenyl)-3-(4-pentylphenyl)-prop-2-ynyl]-(4-methoxyphenyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(4-fluorobenzylidene)-4-methoxyaniline (39769-08-9,130632-07-4) + 1-ethynyl-4-(n-pentyl)benzene (79887-10-8) → (R)-[1-(4-fluorophenyl)-3-(4-pentylphenyl)-prop-2-ynyl]-(4-methoxyphenyl)amine (1373775-51-9)

Guidance literature:

With tetrakis(actonitrile)copper(I) hexafluorophosphate; 2,6-bis[5',5'-diphenyl-4'-(S)-sec-butyloxazolin-2'-yl]pyridine; In chloroform; at 0 - 25 ℃; for 22h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2011.05.114

Reference yield:

4-fluorobenzaldehyde (459-57-4) → (R)-[1-(4-fluorophenyl)-3-(4-pentylphenyl)-prop-2-ynyl]-(4-methoxyphenyl)amine (1373775-51-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 2,6-bis[5',5'-diphenyl-4'-(S)-sec-butyloxazolin-2'-yl]pyridine; tetrakis(actonitrile)copper(I) hexafluorophosphate / chloroform / 0.25 h / 20 °C / Inert atmosphere

2: 2,6-bis[5',5'-diphenyl-4'-(S)-sec-butyloxazolin-2'-yl]pyridine; tetrakis(actonitrile)copper(I) hexafluorophosphate / chloroform / 22 h / 0 - 25 °C / Inert atmosphere

With tetrakis(actonitrile)copper(I) hexafluorophosphate; 2,6-bis[5',5'-diphenyl-4'-(S)-sec-butyloxazolin-2'-yl]pyridine; In chloroform;

DOI:10.1016/j.tet.2011.05.114

Reference yield:

4-methoxy-aniline (104-94-9) → (R)-[1-(4-fluorophenyl)-3-(4-pentylphenyl)-prop-2-ynyl]-(4-methoxyphenyl)amine (1373775-51-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 2,6-bis[5',5'-diphenyl-4'-(S)-sec-butyloxazolin-2'-yl]pyridine; tetrakis(actonitrile)copper(I) hexafluorophosphate / chloroform / 0.25 h / 20 °C / Inert atmosphere

2: 2,6-bis[5',5'-diphenyl-4'-(S)-sec-butyloxazolin-2'-yl]pyridine; tetrakis(actonitrile)copper(I) hexafluorophosphate / chloroform / 22 h / 0 - 25 °C / Inert atmosphere

With tetrakis(actonitrile)copper(I) hexafluorophosphate; 2,6-bis[5',5'-diphenyl-4'-(S)-sec-butyloxazolin-2'-yl]pyridine; In chloroform;

DOI:10.1016/j.tet.2011.05.114

upstream raw materials:

N-(4-fluorobenzylidene)-4-methoxyaniline

1-ethynyl-4-(n-pentyl)benzene

4-fluorobenzaldehyde

4-methoxy-aniline

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