4-[2,3-Dichloro-4-(cyclopentyl-methyl-carbamoyl)-phenoxy]-butyric acid ethyl ester

Base Information

Chemical Name:4-[2,3-Dichloro-4-(cyclopentyl-methyl-carbamoyl)-phenoxy]-butyric acid ethyl ester
CAS No.:109804-13-9
Molecular Formula:C₁₉H₂₅Cl₂NO₄
Molecular Weight:402.318
Hs Code.:

Synonyms:4-[2,3-Dichloro-4-(cyclopentyl-methyl-carbamoyl)-phenoxy]-butyric acid ethyl ester

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Chemical Property of 4-[2,3-Dichloro-4-(cyclopentyl-methyl-carbamoyl)-phenoxy]-butyric acid ethyl ester

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Technology Process of 4-[2,3-Dichloro-4-(cyclopentyl-methyl-carbamoyl)-phenoxy]-butyric acid ethyl ester

There total 7 articles about 4-[2,3-Dichloro-4-(cyclopentyl-methyl-carbamoyl)-phenoxy]-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 2969-81-5
Ethyl 4-bromobutyrate

: 109803-57-8
N-methyl-N-cyclopentyl-2,3-dichloro-4-hydroxybenzamide

: 109804-13-9
4-[2,3-Dichloro-4-(cyclopentyl-methyl-carbamoyl)-phenoxy]-butyric acid ethyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃;
DOI:10.1021/jm00393a020

Reference yield:

: 1984-59-4
2,3-dichloroanisole

: 109804-13-9
4-[2,3-Dichloro-4-(cyclopentyl-methyl-carbamoyl)-phenoxy]-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 66 percent / Fe, Br₂ / 4 h / 90 °C

2: 1.) Mg, I₂ / 1.) THF, reflux, 2.) THF

3: SOCl₂, DMF / ethyl acetate / 10 h / Heating

4: Et₃N / ethyl acetate / Ambient temperature

5: 1.) NaH / 1.) benzene, reflux, 16 h, 2.) benzene, reflux, 5 h

6: 63 percent / BBr₃ / CH₂Cl₂ / 16 h / Ambient temperature

7: 100 percent / K₂CO₃ / dimethylformamide / 50 °C

With thionyl chloride; bromine; iodine; boron tribromide; iron; sodium hydride; potassium carbonate; magnesium; triethylamine; N,N-dimethyl-formamide; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00393a020

Reference yield:

: 55901-80-9
2,3-dichloro-4-methoxy-benzoic acid

: 109804-13-9
4-[2,3-Dichloro-4-(cyclopentyl-methyl-carbamoyl)-phenoxy]-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: SOCl₂, DMF / ethyl acetate / 10 h / Heating

2: Et₃N / ethyl acetate / Ambient temperature

3: 1.) NaH / 1.) benzene, reflux, 16 h, 2.) benzene, reflux, 5 h

4: 63 percent / BBr₃ / CH₂Cl₂ / 16 h / Ambient temperature

5: 100 percent / K₂CO₃ / dimethylformamide / 50 °C

With thionyl chloride; boron tribromide; sodium hydride; potassium carbonate; triethylamine; N,N-dimethyl-formamide; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00393a020