55901-80-9

Upstream product

• 124-38-9 carbon dioxide 
• 54135-80-7 1,2,3-trichloro-4-methoxybenzene 
• 109803-52-3 1-bromo-2,3-dichloro-4-methoxybenzene 
• 576-24-9 2,3-dichlorophenol 
• 1940-44-9 4-bromo-2,3-dichlorophenol 
• 1984-59-4 2,3-dichloroanisole 

Downstream Products

• 76238-31-8 2,3-dichloro-4-methoxybenzoyl chloride 
• 515846-52-3 (R)-[1-(2-{4-[5-(2,3-dichloro-4-methoxy-phenyl)-2-methyl-2H-pyrazol-3-yl]-piperidin-1-yl}-2-oxo-ethylcarbamoyl)-3-methyl-butyl]-carbamic acid tert-butyl ester 
• 164341-36-0 2,3-Dichloro-4-methoxybenzoylguanidine hydrochloride 
• 109804-13-9 4-[2,3-Dichloro-4-(cyclopentyl-methyl-carbamoyl)-phenoxy]-butyric acid ethyl ester 
• 109804-10-6 4-(2,3-Dichloro-4-cyclopentylcarbamoyl-phenoxy)-butyric acid ethyl ester 
• 109804-45-7 4-[2,3-Dichloro-4-(cyclopentyl-methyl-carbamoyl)-phenoxy]-butyric acid 
• 109804-42-4 4-(2,3-Dichloro-4-cyclopentylcarbamoyl-phenoxy)-butyric acid 
• 109803-56-7 N-methyl-N-cyclopentyl-2,3-dichloro-4-methoxybenzamide 
• 109803-57-8 N-methyl-N-cyclopentyl-2,3-dichloro-4-hydroxybenzamide 
• 109803-53-4 N-cyclopentyl-2,3-dichloro-4-methoxybenzamide 
• 109803-59-0 N-cyclopentyl-2,3-dichloro-4-hydroxybenzamide 

Relevant academic research and scientific papers

Electrosynthesis of aryl-carboxylic acids from chlorobenzene derivatives and carbon dioxide

The electrocarboxylation of a large variety of chlorobenzenic compounds is achieved in N,N-dimethylformamide by constant current electrolysis between a stainless steel cathode and a sacrificial magnesium anode in a diaphragmless cell. Substituted benzoic acids are obtained in high yield in simle conditions thus avoiding the usual preparation of organometallic intermediates.

Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: An approach for inhibiting protein-protein interactions

Fragment assembly has shown promise for discovering small-molecule antagonists for difficult targets, including protein-protein interactions. Here, we describe a process for identifying a 60 nM inhibitor of the interleukin-2 (IL-2)/IL-2 receptor (IL-2Rα)

Discovery of a potent small molecule IL-2 inhibitor through fragment assembly

Using a site-directed fragment discovery method called tethering, we have identified a 60 nM small molecule antagonist of a cytokine/receptor interaction (IL-2/IL2Rα) with cell-based activity. Starting with a low micromolar hit, we employed a combination

2,3-Dichloro-4-hydroxy-benzoic acid and process for preparation thereof

A Reimer-Tiemann reaction of 2,3-dichlorophenol with carbon tetrachloride gives 2,3-dichloro-4-hydroxy-benzoic acid, a novel intermediate, which is then reacted with thiophene in the presence of phosphorus pentoxide or polyphosphoric acid to give 2,3-dichloro-4-(2-thienoyl)-phenol. This compound is then converted to the diuretic, ticrynafen, by known prior art reactions.