Technology Process of (S)-(-)-N-(1-(4-iodophenyl)ethyl)diphenylphosphinamide
There total 3 articles about (S)-(-)-N-(1-(4-iodophenyl)ethyl)diphenylphosphinamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tris(triphenylphosphine)ruthenium(II) chloride; C30H37N2OP; potassium tert-butylate; hydrogen;
In
toluene;
at 25 ℃;
for 24h;
under 38002.6 Torr;
enantioselective reaction;
Autoclave;
DOI:10.1002/cjoc.201800343
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine / dichloromethane; hexane / 0.17 h / -40 °C / Inert atmosphere
1.2: -40 - 20 °C / Inert atmosphere
2.1: zinc diacetate; (1R,2R)-N,N’-dibenzyl-1,2-diphenylethane-1,2-diamine / tetrahydrofuran; methanol / 24 h / 20 °C / Inert atmosphere
With
zinc diacetate; (1R,2R)-N,N’-dibenzyl-1,2-diphenylethane-1,2-diamine; triethylamine;
In
tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/acs.joc.5b02613
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 1 h / Reflux
2.1: triethylamine / dichloromethane; hexane / 0.17 h / -40 °C / Inert atmosphere
2.2: -40 - 20 °C / Inert atmosphere
3.1: zinc diacetate; (1R,2R)-N,N’-dibenzyl-1,2-diphenylethane-1,2-diamine / tetrahydrofuran; methanol / 24 h / 20 °C / Inert atmosphere
With
hydroxylamine hydrochloride; zinc diacetate; sodium acetate; (1R,2R)-N,N’-dibenzyl-1,2-diphenylethane-1,2-diamine; triethylamine;
In
tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water;
DOI:10.1021/acs.joc.5b02613
