4-[2-(4-ethoxyphenyl)-4-phenyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl]benzonitrile

Base Information

• Chemical Name: 4-[2-(4-ethoxyphenyl)-4-phenyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl]benzonitrile
• CAS No.: 1334106-88-5
• Molecular Formula: C₂₇H₂₀N₄O
• Molecular Weight: 416.482

Synonyms:4-[2-(4-ethoxyphenyl)-4-phenyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl]benzonitrile

Chemical Property of 4-[2-(4-ethoxyphenyl)-4-phenyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl]benzonitrile

Chemical Property:

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Technology Process of 4-[2-(4-ethoxyphenyl)-4-phenyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl]benzonitrile

There total 6 articles about 4-[2-(4-ethoxyphenyl)-4-phenyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-iodobenzonitrile (3058-39-7) + 2-(4-ethoxyphenyl)-4-phenyl-7H-pyrrolo[2,3-d]pyrimidine (1334106-85-2) → 4-[2-(4-ethoxyphenyl)-4-phenyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl]benzonitrile (1334106-88-5)

Guidance literature:

2-(4-ethoxyphenyl)-4-phenyl-7H-pyrrolo[2,3-d]pyrimidine; With potassium phosphate; copper(l) iodide; In 1,4-dioxane; for 0.166667h; Inert atmosphere;

4-iodobenzonitrile; With trans-1,2-Diaminocyclohexane; In 1,4-dioxane; for 6h; Inert atmosphere; Reflux;

DOI:10.1055/s-0030-1260931

Reference yield:

2-chloro-4-phenyl-7H-pyrrolo[2,3-d]pyrimidine (1236078-07-1) → 4-[2-(4-ethoxyphenyl)-4-phenyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl]benzonitrile (1334106-88-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 1.33 h / Reflux

2.1: palladium diacetate; CyJohnPhos / 1,4-dioxane / 0.17 h / Inert atmosphere

2.2: 4 h / Reflux; Inert atmosphere

3.1: hydrogenchloride / water; acetone / 168 h / Reflux

4.1: copper(l) iodide; potassium phosphate / 1,4-dioxane / 0.17 h / Inert atmosphere

4.2: 6 h / Inert atmosphere; Reflux

With hydrogenchloride; dmap; potassium phosphate; copper(l) iodide; palladium diacetate; N-ethyl-N,N-diisopropylamine; CyJohnPhos; In 1,4-dioxane; dichloromethane; water; acetone; 2.1: Suzuki coupling / 2.2: Suzuki coupling;

DOI:10.1055/s-0030-1260931

Reference yield:

tert-butyl 2-(4-ethoxyphenyl)-4-phenyl-7H-pyrrolo[2,3-d]pyrimidine-7-carboxylate (1334106-82-9) → 4-[2-(4-ethoxyphenyl)-4-phenyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl]benzonitrile (1334106-88-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / water; acetone / 168 h / Reflux

2.1: copper(l) iodide; potassium phosphate / 1,4-dioxane / 0.17 h / Inert atmosphere

2.2: 6 h / Inert atmosphere; Reflux

With hydrogenchloride; potassium phosphate; copper(l) iodide; In 1,4-dioxane; water; acetone;

DOI:10.1055/s-0030-1260931

upstream raw materials:

2-chloro-4-phenyl-7H-pyrrolo[2,3-d]pyrimidine

tert-butyl 2-chloro-4-phenyl-7H-pyrrolo[2,3-d]pyrimidine-7-carboxylate

tert-butyl 2-(4-ethoxyphenyl)-4-phenyl-7H-pyrrolo[2,3-d]pyrimidine-7-carboxylate

4-iodobenzonitrile

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