N-(3-(2-amino-4-(oxazol-4-yl)phenylamino)-5-(1H-pyrazol-1-yl)phenyl)-acetamide

Base Information

Chemical Name:N-(3-(2-amino-4-(oxazol-4-yl)phenylamino)-5-(1H-pyrazol-1-yl)phenyl)-acetamide
CAS No.:1430728-15-6
Molecular Formula:C₂₀H₁₈N₆O₂
Molecular Weight:374.402
Hs Code.:

Synonyms:N-(3-(2-amino-4-(oxazol-4-yl)phenylamino)-5-(1H-pyrazol-1-yl)phenyl)-acetamide

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Chemical Property of N-(3-(2-amino-4-(oxazol-4-yl)phenylamino)-5-(1H-pyrazol-1-yl)phenyl)-acetamide

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Technology Process of N-(3-(2-amino-4-(oxazol-4-yl)phenylamino)-5-(1H-pyrazol-1-yl)phenyl)-acetamide

There total 10 articles about N-(3-(2-amino-4-(oxazol-4-yl)phenylamino)-5-(1H-pyrazol-1-yl)phenyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1430728-14-5
N-(3-(2-nitro-4-(oxazol-4-yl)phenylamino)-5-(1H-pyrazol-1-yl)phenyl)-acetamide

: 1430728-15-6
N-(3-(2-amino-4-(oxazol-4-yl)phenylamino)-5-(1H-pyrazol-1-yl)phenyl)-acetamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; ethyl acetate; for 4h; Inert atmosphere;

Reference yield:

: 42564-51-2
4-fluoro-3-nitrobenzaldehyde

: 1430728-15-6
N-(3-(2-amino-4-(oxazol-4-yl)phenylamino)-5-(1H-pyrazol-1-yl)phenyl)-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium fluoride / N,N-dimethyl-formamide / 4 h / 130 °C

2.1: potassium fluoride / methanol / 0.17 h / 20 °C

2.2: 4 h / Reflux

3.1: palladium 10% on activated carbon / methanol; ethyl acetate / 4 h / Inert atmosphere

With potassium fluoride; palladium 10% on activated carbon; In methanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 18242-39-2
3,5-dinitrobromobenzene

: 1430728-15-6
N-(3-(2-amino-4-(oxazol-4-yl)phenylamino)-5-(1H-pyrazol-1-yl)phenyl)-acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic acid; iron / acetic acid / 0.5 h / 90 °C

2.1: 0.5 h / 0 - 20 °C

3.1: caesium carbonate; copper(I) oxide / N,N-dimethyl-formamide / 16 h / 120 °C

4.1: water; calcium chloride; iron / ethanol / 4 h / 100 °C

5.1: potassium fluoride / N,N-dimethyl-formamide / 4 h / 130 °C

6.1: potassium fluoride / methanol / 0.17 h / 20 °C

6.2: 4 h / Reflux

7.1: palladium 10% on activated carbon / methanol; ethyl acetate / 4 h / Inert atmosphere

With copper(I) oxide; potassium fluoride; palladium 10% on activated carbon; water; iron; caesium carbonate; acetic acid; calcium chloride; In methanol; ethanol; acetic acid; ethyl acetate; N,N-dimethyl-formamide;