(4R,6S)-6-[(R)-2-Hydroxy-1-(4-methoxy-benzyloxy)-ethyl]-4-methyl-tetrahydro-pyran-2-one

Base Information

Chemical Name:(4R,6S)-6-[(R)-2-Hydroxy-1-(4-methoxy-benzyloxy)-ethyl]-4-methyl-tetrahydro-pyran-2-one
CAS No.:343783-00-6
Molecular Formula:C₁₆H₂₂O₅
Molecular Weight:294.348
Hs Code.:

Synonyms:(4R,6S)-6-[(R)-2-Hydroxy-1-(4-methoxy-benzyloxy)-ethyl]-4-methyl-tetrahydro-pyran-2-one

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Chemical Property of (4R,6S)-6-[(R)-2-Hydroxy-1-(4-methoxy-benzyloxy)-ethyl]-4-methyl-tetrahydro-pyran-2-one

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Technology Process of (4R,6S)-6-[(R)-2-Hydroxy-1-(4-methoxy-benzyloxy)-ethyl]-4-methyl-tetrahydro-pyran-2-one

There total 13 articles about (4R,6S)-6-[(R)-2-Hydroxy-1-(4-methoxy-benzyloxy)-ethyl]-4-methyl-tetrahydro-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 343782-88-7
(4R,6S)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(4-methoxy-benzyloxy)-ethyl]-4-methyl-tetrahydro-pyran-2-one

: 343783-00-6
(4R,6S)-6-[(R)-2-Hydroxy-1-(4-methoxy-benzyloxy)-ethyl]-4-methyl-tetrahydro-pyran-2-one

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 3h;
DOI:10.1002/1521-3773(20010401)40:7<1262::AID-ANIE1262>3.0.CO;2-9

Reference yield:

: 343782-87-6
(S)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(4-methoxy-benzyloxy)-ethyl]-5,6-dihydro-pyran-2-one

: 343783-00-6
(4R,6S)-6-[(R)-2-Hydroxy-1-(4-methoxy-benzyloxy)-ethyl]-4-methyl-tetrahydro-pyran-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: CuCN / diethyl ether / 1 h / -78 - 0 °C

1.2: 95 percent / diethyl ether / 0.33 h / -78 °C

2.1: 87 percent / TBAF / tetrahydrofuran / 0.5 h / 25 °C

With tetrabutyl ammonium fluoride; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ja0547477

Reference yield:

: 866454-44-6
(2R)-3-[(tert-butyldiphenylsilyl)oxy]-2-(4-methoxybenzyloxy)propanal

: 343783-00-6
(4R,6S)-6-[(R)-2-Hydroxy-1-(4-methoxy-benzyloxy)-ethyl]-4-methyl-tetrahydro-pyran-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 100 percent / diethyl ether / 2 h / -100 °C

2.1: 78 percent / 4-dimethylaminopyridine; DCC / CH₂Cl₂ / 4 h / Heating

3.1: 91 percent / Grubbs first generation catalyst / CH₂Cl₂ / 4 h / Heating

4.1: CuCN / diethyl ether / 1 h / -78 - 0 °C

4.2: 95 percent / diethyl ether / 0.33 h / -78 °C

5.1: 87 percent / TBAF / tetrahydrofuran / 0.5 h / 25 °C

With dmap; Grubbs catalyst first generation; tetrabutyl ammonium fluoride; dicyclohexyl-carbodiimide; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ja0547477