tert-butyl 2-[2-cyclohexyl-3-(4-methylthiophenyl)imidazolidino[1,2-d]pyrazol-4-yl]acetate

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Chemical Name:tert-butyl 2-[2-cyclohexyl-3-(4-methylthiophenyl)imidazolidino[1,2-d]pyrazol-4-yl]acetate
CAS No.:691881-27-3
Molecular Formula:C₂₄H₃₃N₃O₂S
Molecular Weight:427.611
Hs Code.:

Synonyms:tert-butyl 2-[2-cyclohexyl-3-(4-methylthiophenyl)imidazolidino[1,2-d]pyrazol-4-yl]acetate

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Chemical Property of tert-butyl 2-[2-cyclohexyl-3-(4-methylthiophenyl)imidazolidino[1,2-d]pyrazol-4-yl]acetate

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Technology Process of tert-butyl 2-[2-cyclohexyl-3-(4-methylthiophenyl)imidazolidino[1,2-d]pyrazol-4-yl]acetate

There total 7 articles about tert-butyl 2-[2-cyclohexyl-3-(4-methylthiophenyl)imidazolidino[1,2-d]pyrazol-4-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 691881-23-9
1-(2-cyclohexylimidazolidino[1,2-d]pyrazol-3-yl)-4-methylthiobenzene

: 691881-27-3
tert-butyl 2-[2-cyclohexyl-3-(4-methylthiophenyl)imidazolidino[1,2-d]pyrazol-4-yl]acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 120h;
DOI:10.1016/j.bmc.2004.01.012

Reference yield:

: 3446-90-0
4-(methylthio)benzyl alcohol

: 691881-27-3
tert-butyl 2-[2-cyclohexyl-3-(4-methylthiophenyl)imidazolidino[1,2-d]pyrazol-4-yl]acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 97 percent / thionyl chloride / toluene / 0.5 h / 20 °C

2.1: 89 percent / dimethylsulfoxide / 2 h / 20 °C

3.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 1.17 h / -78 - 20 °C

3.2: 67 percent / tetrahydrofuran / 2.5 h / -78 - 0 °C

4.1: 64 percent / glacial AcOH / 1 h / 100 °C

5.1: 64 percent / triethylamine / CH₂Cl₂ / 0.17 h / 0 °C

6.1: 44 percent / potassium carbonate / dimethylformamide / 17 h / 20 - 60 °C

7.1: 80 percent / K₂CO₃ / dimethylformamide / 120 h / 20 °C

With thionyl chloride; potassium carbonate; acetic acid; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2004.01.012

Reference yield:

: 874-87-3
1-(chloromethyl)-4-methylthiobenzene

: 691881-27-3
tert-butyl 2-[2-cyclohexyl-3-(4-methylthiophenyl)imidazolidino[1,2-d]pyrazol-4-yl]acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 89 percent / dimethylsulfoxide / 2 h / 20 °C

2.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 1.17 h / -78 - 20 °C

2.2: 67 percent / tetrahydrofuran / 2.5 h / -78 - 0 °C

3.1: 64 percent / glacial AcOH / 1 h / 100 °C

4.1: 64 percent / triethylamine / CH₂Cl₂ / 0.17 h / 0 °C

5.1: 44 percent / potassium carbonate / dimethylformamide / 17 h / 20 - 60 °C

6.1: 80 percent / K₂CO₃ / dimethylformamide / 120 h / 20 °C

With potassium carbonate; acetic acid; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2004.01.012