4-[3-(5-amino-2-furan-2-yl-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-propyl]-benzonitrile

Base Information

• Chemical Name: 4-[3-(5-amino-2-furan-2-yl-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-propyl]-benzonitrile
• CAS No.: 396124-22-4
• Molecular Formula: C₂₀H₁₆N₈O
• Molecular Weight: 384.4

Synonyms:4-[3-(5-amino-2-furan-2-yl-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-propyl]-benzonitrile

Chemical Property of 4-[3-(5-amino-2-furan-2-yl-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-propyl]-benzonitrile

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Technology Process of 4-[3-(5-amino-2-furan-2-yl-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-propyl]-benzonitrile

There total 2 articles about 4-[3-(5-amino-2-furan-2-yl-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-propyl]-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

4-(3-chloropropyl)benzenecarbonitrile (131888-47-6) + 2-furan-2-yl-7H-pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidin-5-yl amine (162401-16-3,321661-12-5) → 4-[3-(5-amino-2-furan-2-yl-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-propyl]-benzonitrile (396124-22-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃;

DOI:10.1021/jm010924c

Reference yield:

4-(3-Hydroxypropyl)benzonitrile (83101-12-6) → 4-[3-(5-amino-2-furan-2-yl-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-propyl]-benzonitrile (396124-22-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / SOCl₂; pyridine / benzene / 2 h / 20 °C

2: 65 percent / K₂CO₃ / dimethylformamide / 100 °C

With pyridine; thionyl chloride; potassium carbonate; In N,N-dimethyl-formamide; benzene;

DOI:10.1021/jm010924c

Reference yield: 96.0%

4-[3-(5-amino-2-furan-2-yl-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-propyl]-benzonitrile (396124-22-4) → 4-[3-(5-amino-2-furan-2-ylpyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl]-N-hydroxybenzamidine (396124-26-8)

Guidance literature:

With hydroxylamine hydrochloride; triethylamine; In methanol; at 50 ℃; for 18h;

DOI:10.1021/jm010924c

upstream raw materials:

4-(3-chloropropyl)benzenecarbonitrile

2-furan-2-yl-7H-pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidin-5-yl amine

4-(3-Hydroxypropyl)benzonitrile

Downstream raw materials:

4-[3-(5-amino-2-furan-2-ylpyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl]-N-hydroxybenzamidine

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