2-[1-(2-Hydroxymethyl-phenylamino)-meth-(Z)-ylidene]-3-oxo-hexanoic acid ethyl ester

Base Information

Chemical Name:2-[1-(2-Hydroxymethyl-phenylamino)-meth-(Z)-ylidene]-3-oxo-hexanoic acid ethyl ester
CAS No.:125500-85-8
Molecular Formula:C₁₆H₂₁NO₄
Molecular Weight:291.347
Hs Code.:

Synonyms:2-[1-(2-Hydroxymethyl-phenylamino)-meth-(Z)-ylidene]-3-oxo-hexanoic acid ethyl ester

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Chemical Property of 2-[1-(2-Hydroxymethyl-phenylamino)-meth-(Z)-ylidene]-3-oxo-hexanoic acid ethyl ester

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Technology Process of 2-[1-(2-Hydroxymethyl-phenylamino)-meth-(Z)-ylidene]-3-oxo-hexanoic acid ethyl ester

There total 1 articles about 2-[1-(2-Hydroxymethyl-phenylamino)-meth-(Z)-ylidene]-3-oxo-hexanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 5344-90-1
2-Aminobenzyl alcohol

: 125500-84-7
ethyl 2-(ethoxymethylene)-3-oxohexanoate

: 125500-85-8
2-[1-(2-Hydroxymethyl-phenylamino)-meth-(Z)-ylidene]-3-oxo-hexanoic acid ethyl ester

Guidance literature:: at 100 ℃; for 0.166667h;
DOI:10.1021/jm00014a026

Reference yield: 58.0%

: 100-07-2
4-methoxy-benzoyl chloride

: 125500-85-8
2-[1-(2-Hydroxymethyl-phenylamino)-meth-(Z)-ylidene]-3-oxo-hexanoic acid ethyl ester

: 125500-42-7
4-Methoxy-benzoic acid 2-((Z)-2-ethoxycarbonyl-3-oxo-hex-1-enylamino)-benzyl ester

Guidance literature:: With pyridine; for 16h;
DOI:10.1021/jm00014a026

Reference yield:

: 125500-85-8
2-[1-(2-Hydroxymethyl-phenylamino)-meth-(Z)-ylidene]-3-oxo-hexanoic acid ethyl ester

: 1-[8-(3-Hydroxy-propyl)-4-o-tolylamino-quinolin-3-yl]-butan-1-one

Guidance literature:: Multi-step reaction with 9 steps

1: 58 percent / pyridine / 16 h

2: 54 percent / diphenyl ether / 0.5 h / Heating

3: POCl₃ / 0.5 h / Heating

4: dioxane / Heating

5: KOH / ethanol / 0.5 h

6: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -60 deg C, 30 min, 2.) CH₂Cl₂, from -60 deg C to RT

7: 32 percent / CH₂Cl₂; tetrahydrofuran / 0.5 h / Ambient temperature

8: 67 percent / CF₃COOH / 16 h / Ambient temperature

9: H₂ / 10percent Pd/C / ethanol / 2 h / 2585.7 Torr

With pyridine; potassium hydroxide; oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; diphenylether; ethanol; dichloromethane;
DOI:10.1021/jm00014a026