(1S,2R,1'S,2'R)-Methyl 1--2-phenylcyclopropane-1-carboxylate

Base Information

Chemical Name:(1S,2R,1'S,2'R)-Methyl 1--2-phenylcyclopropane-1-carboxylate
CAS No.:151843-15-1
Molecular Formula:C₂₅H₂₅NO₃
Molecular Weight:387.478
Hs Code.:

(1S,2R,1'S,2'R)-Methyl 1-<N-(1',2'-diphenyl-2'-hydroxyethyl)amino>-2-phenylcyclopropane-1-carboxylate

Synonyms:(1S,2R,1'S,2'R)-Methyl 1--2-phenylcyclopropane-1-carboxylate

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Chemical Property of (1S,2R,1'S,2'R)-Methyl 1--2-phenylcyclopropane-1-carboxylate

Chemical Property:

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Technology Process of (1S,2R,1'S,2'R)-Methyl 1--2-phenylcyclopropane-1-carboxylate

There total 1 articles about (1S,2R,1'S,2'R)-Methyl 1--2-phenylcyclopropane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (1R,3S,5S,6R)-8-Oxo-1,5,6-triphenyl-7-oxa-4-aza-spiro[2.5]octane-4-carboxylic acid tert-butyl ester

: 151843-15-1
(1S,2R,1'S,2'R)-Methyl 1--2-phenylcyclopropane-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / TFA / CH₂Cl₂ / 17 h / Ambient temperature

2: 85 percent / LiOH*H₂O / ethanol / 0.5 h / Heating

3: 89 percent / diethyl ether; methanol / Ambient temperature

With lithium hydroxide; trifluoroacetic acid; In methanol; diethyl ether; ethanol; dichloromethane;
DOI:10.1021/jo00076a077

Reference yield:

: 151843-15-1
(1S,2R,1'S,2'R)-Methyl 1--2-phenylcyclopropane-1-carboxylate

: 151843-16-2
(1S,2R)-2-Phenyl-1-{[1-phenyl-meth-(E)-ylidene]-amino}-cyclopropanecarboxylic acid methyl ester

Guidance literature:: With palladium(II) acetate; In methanol; dichloromethane; at -15 ℃; for 0.0333333h; Yield given;
DOI:10.1021/jo00076a077

Reference yield:

: 151843-15-1
(1S,2R,1'S,2'R)-Methyl 1--2-phenylcyclopropane-1-carboxylate

: 86087-21-0
(1S,2R)-(E)-(+)-1-amino-2-phenyl-1-cyclopropane-1-carboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: Pd(OAc)4 / methanol; CH₂Cl₂ / 0.03 h / -15 °C

2: 1 M aq. HCl / tetrahydrofuran / 0.25 h / Ambient temperature

3: Et₃N / tetrahydrofuran / 1.) room temp., 2.) room temp., 24 h

4: 97 percent / LiOH*H₂O / methanol; H₂O / 2.5 h / Heating

5: 90 percent / 1 N HCl / methanol / 1.) -15 deg C, 4 h, 2.) room temp., 1 h

With palladium(II) acetate; hydrogenchloride; lithium hydroxide; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jo00076a077