86087-21-0

Basic information

• Product Name: (1S,2R)-(E)-(+)-1-amino-2-phenyl-1-cyclopropane-1-carboxylic acid hydrochloride
• Synonyms: (1S,2R)-(E)-(+)-1-amino-2-phenyl-1-cyclopropane-1-carboxylic acid hydrochloride
• CAS NO: 86087-21-0
• Molecular Weight: 213.664
• Mol File: 86087-21-0.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: (1S,2R)-(E)-(+)-1-amino-2-phenyl-1-cyclopropane-1-carboxylic acid hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2R)-(E)-(+)-1-amino-2-phenyl-1-cyclopropane-1-carboxylic acid hydrochloride(86087-21-0)
• EPA Substance Registry System: (1S,2R)-(E)-(+)-1-amino-2-phenyl-1-cyclopropane-1-carboxylic acid hydrochloride(86087-21-0)

Safety Data

• Hazardous Substances Data: 86087-21-0(Hazardous Substances Data)

Upstream product

• 97364-86-8 (1S,2S)-1-Isocyanato-2-phenyl-cyclopropanecarboxylic acid methyl ester 
• 151843-15-1 (1S,2R,1'S,2'R)-Methyl 1--2-phenylcyclopropane-1-carboxylate 
• 151843-16-2 (1S,2R)-2-Phenyl-1-{[1-phenyl-meth-(E)-ylidene]-amino}-cyclopropanecarboxylic acid methyl ester 
• 151910-11-1 (1S,2R)-1--2-phenylcyclopropane-1-carboxylic acid 
• 86087-19-6 (1S,2R)-1-Benzyloxycarbonylamino-2-phenyl-cyclopropanecarboxylic acid 
• 669058-56-4 ethyl 1-amino-2-phenyl-1-cyclopropanecarboxylate 
• 87378-79-8 methyl (Z)-1-<1-(N-imidazolyl)benzylideneamino>-2-phenylcyclopropanecarboxylate 
• 17606-70-1 (4Z)-4-benzylidene-2-phenyl-1,3-oxazol-5(4H)-one 
• 4525-04-6 (Z)-(1,5-diphenyl)-7-oxo-6-oxa-4-azaspiro<2.4>hept-4-ene 
• 97364-76-6 1-methoxycarbonyl-2-phenylcyclopropanecarboxylic acid 
• 100-52-7 benzaldehyde 
• 1666-17-7 (E)-N′-benzylidene-4-methylbenzenesulfonohydrazide 
• 87378-73-2 methyl (1RS,2RS)-1-(acetylamino)-2-phenyl-1-cyclopropanecarboxylate 
• 70315-54-7 methyl 1-benzamido-2-phenyl-cyclopropanecarboxylate 

Relevant articles and documents

Expanding the scope of donor/acceptor carbenes to N -phthalimido donor groups: Diastereoselective synthesis of 1-cyclopropane α-amino acids

Warming of 4-phthalimido-N-mesyl-1,2,3-triazole in the presence of alkenes followed by silica gel induced hydrolysis results in a highly diastereoselective and catalyst-free entry to N-phthalimidocyclopropanecarboxaldehydes.

CYCLOPROPANE COMPOUNDS AND PHARMACEUTICAL USE THEREOF

The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula

Diastereoselective Synthesis of Cyclopropane Amino Acids Using Diazo Compounds Generated in Situ

A simple and high-yielding method for the preparation of cyclopropane amino acids is described. The novel method involves the one-pot cyclopropanation of readily available dehydroamino acids using aryl and unsaturated diazo compounds generated in situ fro