4-chloro-1-[2-chloro-2-(4-chlorophenyl)ethyl]-1H-pyrazolo[3,4-d]pyrimidine

Base Information

• Chemical Name: 4-chloro-1-[2-chloro-2-(4-chlorophenyl)ethyl]-1H-pyrazolo[3,4-d]pyrimidine
• CAS No.: 1013930-74-9
• Molecular Formula: C₁₃H₉Cl₃N₄
• Molecular Weight: 327.6

Synonyms:4-chloro-1-[2-chloro-2-(4-chlorophenyl)ethyl]-1H-pyrazolo[3,4-d]pyrimidine

Chemical Property of 4-chloro-1-[2-chloro-2-(4-chlorophenyl)ethyl]-1H-pyrazolo[3,4-d]pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of 4-chloro-1-[2-chloro-2-(4-chlorophenyl)ethyl]-1H-pyrazolo[3,4-d]pyrimidine

There total 3 articles about 4-chloro-1-[2-chloro-2-(4-chlorophenyl)ethyl]-1H-pyrazolo[3,4-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-(4-chloro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-1-(4-chlorophenyl)ethanol (1451010-33-5) → 4-chloro-1-[2-chloro-2-(4-chlorophenyl)ethyl]-1H-pyrazolo[3,4-d]pyrimidine (1013930-74-9)

Guidance literature:

With trichlorophosphate; In N,N-dimethyl-formamide; Reflux; Inert atmosphere;

DOI:10.1016/j.tetlet.2013.07.069

Reference yield:

4-chloro-1H-pyrazolo[3,4-d]pyrimidine (5399-92-8) → 4-chloro-1-[2-chloro-2-(4-chlorophenyl)ethyl]-1H-pyrazolo[3,4-d]pyrimidine (1013930-74-9)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere

2: sodium tetrahydroborate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: trichlorophosphate / N,N-dimethyl-formamide / Reflux; Inert atmosphere

With sodium tetrahydroborate; tetrabutyl ammonium fluoride; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2013.07.069

Reference yield:

2-(4-chloro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-1-(4-chlorophenyl)ethanone (1451010-30-2) → 4-chloro-1-[2-chloro-2-(4-chlorophenyl)ethyl]-1H-pyrazolo[3,4-d]pyrimidine (1013930-74-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: trichlorophosphate / N,N-dimethyl-formamide / Reflux; Inert atmosphere

With sodium tetrahydroborate; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2013.07.069

upstream raw materials:

4-chloro-1H-pyrazolo[3,4-d]pyrimidine

2-(4-chloro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-1-(4-chlorophenyl)ethanone

2-(4-chloro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-1-(4-chlorophenyl)ethanol

Downstream raw materials:

C₂₀H₁₆Cl₃N₅

(4-(4-(1-(2-chloro-2-(4-chlorophenyl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl)phenyl)methanamine

1-(2-chloro-2-(4-chlorophenyl)ethyl)-N-(4-(4-methylpiperazin-1-yl)benzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

1-[2-chloro-2-(4-chlorophenyl)ethyl]-N-(pyridin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

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