1-[2-chloro-2-(4-chlorophenyl)ethyl]-N-(pyridin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Base Information

Chemical Name:1-[2-chloro-2-(4-chlorophenyl)ethyl]-N-(pyridin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS No.:1283727-50-3
Molecular Formula:C₁₉H₁₆Cl₂N₆
Molecular Weight:399.282
Hs Code.:

Synonyms:1-[2-chloro-2-(4-chlorophenyl)ethyl]-N-(pyridin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

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Chemical Property of 1-[2-chloro-2-(4-chlorophenyl)ethyl]-N-(pyridin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

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Technology Process of 1-[2-chloro-2-(4-chlorophenyl)ethyl]-N-(pyridin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

There total 4 articles about 1-[2-chloro-2-(4-chlorophenyl)ethyl]-N-(pyridin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 3731-53-1
4-(aminomethyl)pyridine

: 1013930-74-9
4-chloro-1-[2-chloro-2-(4-chlorophenyl)ethyl]-1H-pyrazolo[3,4-d]pyrimidine

: 1283727-50-3
1-[2-chloro-2-(4-chlorophenyl)ethyl]-N-(pyridin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Guidance literature:: With acetic acid; In 1,4-dioxane; Microwave irradiation; Heating; Inert atmosphere;
DOI:10.1016/j.tetlet.2013.07.069

Reference yield:

: 5399-92-8
4-chloro-1H-pyrazolo[3,4-d]pyrimidine

: 1283727-50-3
1-[2-chloro-2-(4-chlorophenyl)ethyl]-N-(pyridin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere

2: sodium tetrahydroborate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: trichlorophosphate / N,N-dimethyl-formamide / Reflux; Inert atmosphere

4: acetic acid / 1,4-dioxane / Microwave irradiation; Heating; Inert atmosphere

With sodium tetrahydroborate; tetrabutyl ammonium fluoride; acetic acid; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2013.07.069

Reference yield:

: 1451010-30-2
2-(4-chloro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-1-(4-chlorophenyl)ethanone

: 1283727-50-3
1-[2-chloro-2-(4-chlorophenyl)ethyl]-N-(pyridin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: trichlorophosphate / N,N-dimethyl-formamide / Reflux; Inert atmosphere

3: acetic acid / 1,4-dioxane / Microwave irradiation; Heating; Inert atmosphere

With sodium tetrahydroborate; acetic acid; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2013.07.069