ethyl 2,4(1H,3H)-dioxo-5-methyl-1-(2-methylthiobenzyl)-6-(4-methoxyethylphenyl)thieno[2,3-d]pyrimidine-3-acetate

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Chemical Name:ethyl 2,4(1H,3H)-dioxo-5-methyl-1-(2-methylthiobenzyl)-6-(4-methoxyethylphenyl)thieno[2,3-d]pyrimidine-3-acetate
CAS No.:165809-24-5
Molecular Formula:C₂₈H₃₀N₂O₅S₂
Molecular Weight:538.689
Hs Code.:

Synonyms:ethyl 2,4(1H,3H)-dioxo-5-methyl-1-(2-methylthiobenzyl)-6-(4-methoxyethylphenyl)thieno[2,3-d]pyrimidine-3-acetate

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Chemical Property of ethyl 2,4(1H,3H)-dioxo-5-methyl-1-(2-methylthiobenzyl)-6-(4-methoxyethylphenyl)thieno[2,3-d]pyrimidine-3-acetate

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Technology Process of ethyl 2,4(1H,3H)-dioxo-5-methyl-1-(2-methylthiobenzyl)-6-(4-methoxyethylphenyl)thieno[2,3-d]pyrimidine-3-acetate

There total 7 articles about ethyl 2,4(1H,3H)-dioxo-5-methyl-1-(2-methylthiobenzyl)-6-(4-methoxyethylphenyl)thieno[2,3-d]pyrimidine-3-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: (4-(2-methoxyethyl)phenyl)boronic acid

: 165809-36-9
ethyl 2,4(1H,3H)-dioxo-6-bromo-5-methyl-1-(2-methylthiobenzyl)thieno[2,3-d]pyrimidine-3-acetate

: 165809-24-5
ethyl 2,4(1H,3H)-dioxo-5-methyl-1-(2-methylthiobenzyl)-6-(4-methoxyethylphenyl)thieno[2,3-d]pyrimidine-3-acetate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; for 5h; Heating;
DOI:10.1248/cpb.46.1724

Reference yield: 43.0%

: 165809-24-5
ethyl 2,4(1H,3H)-dioxo-5-methyl-1-(2-methylthiobenzyl)-6-(4-methoxyethylphenyl)thieno[2,3-d]pyrimidine-3-acetate

Guidance literature:

Reference yield:

: 43088-42-2
2-amino-4-methyl-thiophene-3-carboxylic acid ethyl ester

: 165809-24-5
ethyl 2,4(1H,3H)-dioxo-5-methyl-1-(2-methylthiobenzyl)-6-(4-methoxyethylphenyl)thieno[2,3-d]pyrimidine-3-acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) pyridine, 2.) NaOEt / 1.) 45 deg C, 3 h, 2.) EtOH, RT, 1.5 h

2: 90 percent / NBS / CHCl₃ / 2.5 h / Heating

3: 68 percent / K₂CO₃, KI / dimethylformamide / 16 h / Ambient temperature

4: 54 percent / Na₂CO₃, tetrakis(triphenylphosphine)palladium / 1,2-dimethoxy-ethane / 5 h / Heating

With pyridine; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium ethanolate; sodium carbonate; potassium carbonate; potassium iodide; In 1,2-dimethoxyethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.1724