43088-42-2

Basic information

• Product Name: ETHYL 2-AMINO-4-METHYLTHIOPHENE-3-CARBOXYLATE
• Synonyms: 2-AMINO-4-METHYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER;BUTTPARK 29\08-49;ETHYL 2-AMINO-4-METHYLTHIOPHENE-3-CARBOXYLATE;Ethyl 2-amino-4-methyl-3-thiophenecarboxylate;Ethyl 2-amino-4-methylthiophene-3-carboxylate, 98+%;Ethyl 2-amino-4-methylthiophene-3-carboxylate ,97%;3-thiophenecarboxylic acid, 2-amino-4-methyl-, ethyl ester;methyl 2-amino-4-methylthiophene-3-carboxylate
• CAS NO: 43088-42-2
• Molecular Formula: C₈H₁₁NO₂S
• Molecular Weight: 185.24
• EINECS: -0
• Product Categories: Thiophene
• Mol File: 43088-42-2.mol
• Article Data: 16

Chemical Properties

• Melting Point: 80 °C
• Boiling Point: 279℃
• Flash Point: 123℃
• Appearance: /
• Density: 1.219
• Vapor Pressure: 0.00411mmHg at 25°C
• Refractive Index: 1.573
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 0.24±0.10(Predicted)
• Water Solubility: Soluble in water
• BRN: 1366073
• CAS DataBase Reference: ETHYL 2-AMINO-4-METHYLTHIOPHENE-3-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-AMINO-4-METHYLTHIOPHENE-3-CARBOXYLATE(43088-42-2)
• EPA Substance Registry System: ETHYL 2-AMINO-4-METHYLTHIOPHENE-3-CARBOXYLATE(43088-42-2)

Safety Data

• Safety Statements: 24/25
• HazardClass: IRRITANT
• Hazardous Substances Data: 43088-42-2(Hazardous Substances Data)

Usage

Chemical Properties

Yellow solid

InChI:InChI=1/C8H11NO2S/c1-3-11-8(10)6-5(2)4-12-7(6)9/h4H,3,9H2,1-2H3

Upstream product

• 110-91-8 morpholine 
• 105-56-6 ethyl 2-cyanoacetate 
• 67-64-1 acetone 
• 109-89-7 diethylamine 

Downstream Products

• 1345512-82-4 N'-[(2-hydroxyphenyl)methylene]-(4-oxo-5-methyl-thieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone 
• 1345512-83-5 N'-[(4-cyanophenyl)methylene]-(4-oxo-5-methyl-thieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone 
• 1345512-84-6 N'-[(3-nitro-4-chlorophenyl)methylene]-(4-oxo-5-methyl-thieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone 
• 56844-14-5 4,6-dichloro-5-methylthieno[2,3-d]pyrimidine 
• 56844-42-9 6-chloro-5-methylthieno[2,3-d]pyrimidin-4(3H)-one 
• 78071-30-4 4-methylthiophene-3-carboxylic acid 
• 1459129-48-6 O-ethyl P-(4-methoxyphenyl)-N-(4-methylthiophen-2-yl)phosphonamidothioate 
• 1421702-43-3 C₂₀H₂₈N₂O₂S 
• 1421702-86-4 N-cyclohexyl-4,7-dihydro-3-methyl-4-oxothieno[2,3-b]pyridine-5-carboxamide 
• 43088-64-8 5-Methyl-3,4-dihydrothieno<2,3-d>pyrimid-4-one 
• 43139-85-1 2-(benzamido)-3-carboethoxy-4-methylthiophene 
• 43088-64-8 5-methylthieno[2,3-d]pyrimidin-4-ol 
• 122185-82-4 3-(4-bromo-2-fluorobenzyl)-5-methylthieno[2,3-d]-pyrimidine-2,4(1H,3H)-dione 
• 773071-08-2 2-(3-chloromethylbenzoylamino)-4-methyl-thiophene-3-carboxylic acid ethyl ester 

Relevant articles and documents

Pd-containing IL-based ordered nanostructured organosilica: A powerful and recoverable catalyst for Sonogashira reaction

An IL-based ordered nanostructured organosilica supported palladium (Pd@ONO-IL) is synthesized and characterized. The Pd@ONO-IL was used as powerful nanocatalyst in the Sonogashira reaction that the corresponding products were obtained in high yield. The

Preparation method of ACC (acetyl-coA carboxylase) inhibitor drug key intermediate

The invention relates to a method of synthesizing an ACC (acetyl-coA carboxylase) inhibitor drug key intermediate and belongs to the field of chemical synthesis. A target compound is mainly prepared by modifying a starting material and performing Gewald aminothiophene reaction, amide synthesis, closed-loop reaction, bromination and other reactions, the step of alkali hydrolysis of ethyl formate group is not required, next decarboxylation reaction is not required either, the reaction process is shortened, and the preparation method has the advantages of good path stability and safety, low cost, low price and good accessibility of materials, high yield and the like.

Computer-aided identification, synthesis and evaluation of substituted thienopyrimidines as novel inhibitors of HCV replication

A structure-based virtual screening technique was applied to the study of the HCV NS3 helicase, with the aim to find novel inhibitors of the HCV replication. A library of ～450000 commercially available compounds was analysed in silico and 21 structures were selected for biological evaluation in the HCV replicon assay. One hit characterized by a substituted thieno-pyrimidine scaffold was found to inhibit the viral replication with an EC50value in the sub-micromolar range and a good selectivity index. Different series of novel thieno-pyrimidine derivatives were designed and synthesised; several new structures showed antiviral activity in the low or sub-micromolar range.